西藏拉萨地区成年藏族人群代谢综合征现状调查  

Investigation of metabolic syndrome in adult Tibetan population in Lhasa,Tibet

作　　者：次仁旺姆[1] 罗樱樱[2] 张泽鑫 陈娜 吕雪梅[3] 孟树优[3] 杨森淋[3] 阿米娜[3] 巴桑普赤[3] 李昂[4] 杨丽辉[3] CiRenWangMu;LUO Yingying;ZHANG Zexin;CHEN Na;LYU Xuemei;MENG Shuyou;YANG Senlin;AMiNa;BaSangPuChi;LI Ang;YANG Lihui(Medical College,Tibet University,Lhasa,Tibet 850000,China;Department of Endocrinology,Peking University People′s Hospital,Beijing 100044,China;Department of Endocrinology,People′s Hospital of Tibet Autonomous Region,Lhasa,Tibet 850000,China;Department of Endocrinology,Peking University First Hospital,Beijing 100034,China)

机构地区：[1]西藏大学医学院,拉萨850000 [2]北京大学人民医院内分泌科,100044 [3]西藏自治区人民医院内分泌科,拉萨850000 [4]北京大学第一医院内分泌科,100034

出　　处：《重庆医学》2020年第23期3912-3915,共4页Chongqing medicine

基　　金：西藏大学研究生“高水平人才培养计划”项目(2019YXYYJS022);西藏自治区重大科技项目(XZ201901-GB-06);2017组援医学项目(XZ2017ZR-ZYZ15)。

摘　　要：目的了解西藏拉萨地区成年藏族常住居民代谢综合征(MS)的患病现状及影响因素。方法通过对拉萨及周边地区藏族成年人进行多阶段分层整群随机抽样,依据《2007中国成人血脂异常防治指南》,以大于或等于18岁的藏族人群为调查对象,行体格检查、问卷调查及空腹血糖(FPG)、糖负荷后2 h血糖(OGTT 2 h)、三酰甘油(TG)、总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)等生化指标检测。结果(1)共入组1798例,其中女性1216例。根据《2007中国成人血脂异常防治指南》,MS患病率为38.49%,根据2010年第6次全国人口普查数据,MS标化后患病率23.05%;(2)男性居民MS患病率高于女性,城镇居民高于农村,差异有统计学意义(P<0.05);(3)与非MS组相比,MS组年龄、BMI、腰围、FPG、OGTT 2 h、TG、SBP、DBP均明显升高,差异有统计学意义(P<0.05),HDL-C水平在两组间差异无统计学意义(P>0.05);(4)MS、超重、肥胖、中心性肥胖、高血糖、高血压、高TC、高LDL-C患病率均有随年龄增加呈升高的趋势,且男性高于女性,差异有统计学意义(P<0.05);(5)MS不同组合中以中心性肥胖+高血压+高TG+低HDL-C和中心性肥胖+高血糖+高TG+低HDL-C占比最多;(6)logistic回归分析显示,年龄、性别(女性)、BMI、腰围、OGTT 2 h、DBP是MS的危险因素,HDL-C是MS的保护因素。结论西藏拉萨地区藏族成年人群MS的患病率偏高,需制订更有针对性、科学性的防治措施提高该人群生活质量。Objective To investigate the prevalence and influencing factors of metabolic syndrome(MS)in Tibetan residents in Lhasa,Tibet.Methods Tibetan inhabitants living in Lhasa and the surrounding areas were recruited by the method of multistage randomized cluster sampling.According to the standard Guidelines for prevention and treatment of adult dyslipidemia in China 2007,Tibetans aged 18 and over were selected for physical examination,questionnaires and blood biochemical indicators detection,including fasting blood-glucose(FPG),blood glucose 2 h after glucose load(OGTT 2 h),triacylglycerol(TG),total cholesterol(TC),low density lipoprotein cholesterol(LDL-C),high density lipoprotein cholesterol(HDL-C).Results(1)A total of 1798 people were enrolled,with 1216 female.According to Guidelines for prevention and treatment of adult dyslipidemia in China 2007,the prevalence of MS was 38.49%,which was 23.05%after standardization according to the 6th national census in 2010.(2)The prevalence of MS in male residents was higher than that in female,and the prevalence of metabolic syndrome in urban residents was higher than that in rural residents(P<0.05).(3)Compared with the non-MS group,age,BMI,waist circumference,FPG,OGTT 2 h,TG,SBP and DBP significantly increased in the MS group(P<0.05),while HDL-C level was not significantly different between the two groups(P>0.05).(4)MS,overweight,obesity,center obesity,hyperglycemia,hypertension and high-TC,high LDL-C increased with age,and males were higher than females(P<0.05).(5)Among the different combinations of MS,central obesity+hypertension+high TG+low HDL-C and central obesity+high blood glucose+high TG low HDL-C that accounted for the largest proportion.(6)Logistic regression showed that age,gender(female),BMI,WC,OGTT 2 h,DBP were risk factors for MS.HDL-C was a protective factor for MS.Conclusion The prevalence of MS among Tibetan adults in Lhasa is significantly higher.It is necessary to formulate more targeted and scientific prevention measures to improve the life quality of this

关 键 词：代谢综合征 患病率 拉萨 藏族 现况调查 

分 类 号：R589[医药卫生—内分泌]