子宫内膜局部损伤对冻融胚胎移植妊娠结局的影响  

Effect of endometrial local injury on pregnancy outcomes of frozen-thawed embryo transfer

作　　者：唐志霞 洪名云 何芳 宣恒华 严春 TANG Zhixia;HONG Mingyun;HE Fang;XUAN Henghua;YAN Chun(Reproductive Center,Maternal and Child Health Care Hospital Affiliated to Anhui Medical University/Anhui Maternal and Child Health Care Hospital,Hefei,Anhui 230001,China)

机构地区：[1]安徽医科大学附属妇幼保健院/安徽省妇幼保健院生殖中心,合肥230001

出　　处：《重庆医学》2020年第23期3923-3925,共3页Chongqing medicine

基　　金：安徽省重点研究开发项目(1704a0802171);合肥市应用医学研究项目(hwk2017yb009);合肥市“借转补”项目(J2018Y03)。

摘　　要：目的探讨于月经周期第3天行子宫内膜局部损伤对冻融胚胎移植(F-ET)临床结局的影响。方法选取2017年10月至2019年4月在该中心行冻融胚胎移植的420个周期不孕症患者为研究对象,分为损伤组(210个周期)和对照组(210个周期)。比较两组不孕症患者临床妊娠率、着床率、流产率及多胎妊娠率等。结果损伤组转化日子宫内膜厚度(9.93±1.74)mm明显高于对照组(9.05±1.66)mm,差异有统计学意义(P=0.023)。损伤组转化日A+B型子宫内膜比例(97.14%)明显高于对照组(88.10%),差异有统计学意义(P<0.001);转化日内膜有血流比例(96.67%)明显高于对照组(89.05%),差异有统计学意义(P=0.003);临床妊娠率(56.19%)、多胎妊娠率(33.90%)和着床率(43.08%)均明显高于对照组,差异有统计学意义(P<0.05)。结论既往移植失败次数大于或等于1次的患者月经周期第3天行子宫内膜局部损伤可以改善子宫内膜形态、血流和F-ET妊娠结局。Objective To explore the effect of endometrial local injury at the 3rd day of menstrual cycle on pregnancy outcomes of frozen-thawed embryo transfer(F-ET).Methods A total of 420 cycles infertility patients undergoing frozen-thawed embryo transfer in the center from October 2017 to April 2019 were selected as study subjects and divided into the injury group(210 cycles)and the control group(210 cycles).The clinical pregnancy rate,implantation rate,abortion rate and multiple pregnancy rate were compared between the two groups.Results The endometral thickness at initiation day in the injury group group(9.93±1.74)mm was significantly higher than the control group(9.05±1.66)mm,which was statistically significant(P=0.023).The proportion of type A+B of endometrum at initiation day in the injury group(97.14%)was significantly higher than that of control group(88.10%),which was statistically significant(P<0.001).The proportion of endometrial blood flow at initiation day in the injury group(96.67%)was significantly higher than that of control group(89.05%),which was statistically significant(P=0.003).The clinical pregnancy rate(56.19%),multiple pregnancy rate(33.90%)and implantation rate(43.08%)were significantly higher in the injury group than those in the control group(P<0.05).Conclusion Endometrial local injury at the 3rd day of menstrual cycle can improve the endometrial morphology,blood flow and F-ET pregnancy outcomes of patients with more than 1 previous transplant failure.

关 键 词：胚胎移植 子宫内膜损伤 着床率 妊娠率 妊娠 多胎 

分 类 号：R711.6[医药卫生—妇产科学]