温和条件下肉桂醛硝酮的合成  

Synthesis of Cinnamaldehyde-Derived Nitrone under Mild Conditions

作　　者：张志豪 张豪 李宜恒 刘益林 Zhang Zhihao;Zhang Hao;Li Yiheng;Liu Yilin(Department of Chemistry and Materials Engineering,Huaihua University,Huaihua 418008,China)

机构地区：[1]怀化学院化学与材料工程学院,湖南怀化418008

出　　处：《广东化工》2020年第21期246-247,共2页Guangdong Chemical Industry

基　　金：湖南省教育厅科研项目(No:19A389);2019年度湖南省大学生创新创业训练计划项目(No:1943)。

摘　　要：硝酮是一类非常重要的合成子。我们发展了一种温和条件下制备肉桂醛硝酮的方法。以肉桂醛和苄基羟胺盐酸盐的反应为模型,考察了溶剂、碱对反应产率的影响,确定了反应的最优条件,研究了苯环上取代基对反应的影响。该方法操作简单、反应条件温和、产率高,为肉桂醛硝酮的合成提供了一种新途径。Nitrone is an important synthon. A method for the synthesis of cinnamaldehyde-derived nitrone under mild conditions was developed. A model reaction of cinnamaldehyde and N-benzylhydroxylamine hydrochloride was choosed to examine the influence of solvent and base on the yield, and the optimized reaction condition was determined;the effect of substituent on the benzene ring on the yield was also explored. The method is simple-operation, mild-conditions, high-yield and provides a novel access to cinnamaldehyde-derived nitrone.

关 键 词：肉桂醛 硝酮 羟胺 

分 类 号：O622.6[理学—有机化学]