右美托咪定对不同组织系统离子通道的作用  

Effect of Dexmedetomidine on Ion Channels in Different Tissues

作　　者：张晓晓[1] 马岳 胡越成[2] 李树华[1] ZHANG Xiaoxiao;MA Yue;HU Yuecheng;LI Shuhua(Department of Anesthesiology,Tianjin Gong′an Hospital,Tianjin 300040,China;Department of Cardiology,Tianjin Chest Hospital,Tianjin 300051,China)

机构地区：[1]天津市公安医院麻醉科,天津300040 [2]天津市胸科医院心内科,天津300051

出　　处：《医学综述》2020年第23期4739-4744,共6页Medical Recapitulate

摘　　要：右美托咪定是选择性α_2肾上腺素能受体激动剂,具有镇静、抗焦虑等药理作用,同时对呼吸影响小,目前已广泛应用于围手术期患者的镇静及止痛。右美托咪定可对缺血再灌注损伤的心肌起到一定的保护作用,低血压、心动过缓是其主要的不良反应,但具体的机制目前尚未明确。另外,右美托咪定还可对不同组织细胞的多种离子通道产生不同的作用,进而发挥抗心律失常以及保护缺血再灌注损伤的作用,如抑制氧化应激、细胞凋亡及炎症反应等。Dexmedetomidine is a selectiveα2 adrenergic receptor agonist,which exert sedative,anti-anxiety and other pharmacological effects.It has been widely used in perioperative patients due to its small effect on respiration.Dexmedetomidine can play a protective role in myocardial ischemia reperfusion injury,while hypotension and bradycardia are the main side effects,but the specific mechanism has not been fully clarified.Besides,dexmedetomidine has different effects on many kinds of ion channels in cells of different tissues,so as to play the roles of antiarrhythmia and protection of ischemia reperfusion injury,such as inhibition of oxidative stress,cell apoptosis and inflammatory response.

关 键 词：右美托咪定 离子通道 缺血再灌注损伤 抗心律失常 

分 类 号：R614.1[医药卫生—麻醉学]