多沙普仑联合BiPAP呼吸机治疗AECOPD伴呼吸衰竭  

Doxapram combined with BiPAP ventilator in the treatment of AECOPD with respiratory failure

作　　者：梁珍珍[1] LIANG Zhen-zhen(Department of Respiratory and Critical Care Medicine,Zhoukou Central Hospital,Zhoukou 466000,China)

机构地区：[1]周口市中心医院呼吸与危重症医学科,河南周口466000

出　　处：《牡丹江医学院学报》2020年第6期78-80,92,共4页Journal of Mudanjiang Medical University

摘　　要：目的研究多沙普仑联合双水平气道正压通气(BiPAP)呼吸机应用于慢性阻塞性肺疾病急性加重期(AECOPD)伴呼吸衰竭的效果。方法选取我院AECOPD伴呼吸衰竭患者90例,其中45例采用BiPAP呼吸机治疗为通气组,45例采用多沙普仑联合BiPAP呼吸机治疗为联合组。比较两组疗效、治疗前、治疗6 d后呼吸频率、分钟通气量、动脉血气指标[动脉血氧分压(PaO2)、动脉血二氧化碳分压(PaCO2)]及血清细胞因子水平[髓样细胞触发受体1(TREM-1)、表面活性蛋白D(SP-D)、克拉拉细胞蛋白(CC16)]。结果联合组总有效率91.11%高于通气组73.33%(P<0.05);治疗6 d后联合组呼吸频率小于通气组,分钟通气量大于通气组(P<0.05);治疗6 d后联合组PaCO2小于通气组,PaO2大于通气组(P<0.05);治疗6 d后联合组血清TREM-1、SP-D水平低于通气组,CC16水平高于通气组(P<0.05)。结论多沙普仑联合BiPAP呼吸机治疗AECOPD伴呼吸衰竭疗效显著,能减小呼吸频率,增大分钟通气量,改善血气指标,调节血清细胞因子水平。Objective To investigate the effect of Doxaprom combined with BiPAP ventilator on acute exacerbation of chronic obstructive pulmonary disease(AECOPD)with respiratory failure.Methods Ninety patients with AECOPD associated with respiratory failure in our hospital(From December 2017 to December 2019)were selected,among which 45 patients were treated with BiPAP ventilator as ventilation group,and 45 patients were treated with Doxaprom combined with BiPAP ventilator as combination group.The curative effect of the two groups were compared,before and after 6 d treatment respiratory frequency,including minute ventilation,arterial blood gas index[arterial blood oxygen partial pressure,arterial blood(PaO 2)CO 2 partial pressure(PaCO2)]and serum levels of cytokines[myeloid cells trigger receptor 1(TREM-1),the surfactant protein D(SP-D),Clara cell protein(CC16)].Results The total effective rate of the combined group was 91.11%,which was higher than that of the ventilation group 73.33%,(P<0.05).After treatment for 6 days,the respiratory rate of the combined group was lower than that of the ventilation group,and the minute ventilation rate was higher than that of the ventilation group(P<0.05).After 6 days of treatment,PaCO2 in the combination group was lower than that in the ventilation group,and PaO2 was higher than that in the ventilation group(P<0.05).After 6 days of treatment,the serum levels of TRE-1 and SP-D in the combined group were lower than those in the ventilation group,and the levels of CC16 were higher than those in the ventilation group(P<0.05).Conclusion Doxaprom combined with BiPAP ventilator has a significant effect on AECOPD with respiratory failure,which can reduce respiratory frequency,increase minute ventilation,improve blood gas index,and regulate serum cytokine levels.

关 键 词：多沙普仑 BIPAP呼吸机 AECOPD 呼吸衰竭 呼吸频率 分钟通气量 动脉血气指标 

分 类 号：R563.8[医药卫生—呼吸系统]