高血压左心室肥厚患者血清可溶性基质溶素-2、半乳糖凝集素-3的临床价值研究  

Clinical value research of serum soluble matrix lysin-2 and galectin-3 in patients with hypertensive left ventricular hypertrophy

作　　者：袁国良 李伟[1] 田乃亮[2] YUAN Guoliang;LI Wei;TIAN Nailiang(Department of Internal Medicine Cardiovascular,Shuyang Affiliated Hospital of Nanjing University of Traditional Chinese Medicine,Suqian,Jiangsu 223699,China;Department of Internal Medicine Cardiovascular,Nanjing First Hospital Affiliated to Nanjing Medical University,Nanjing,Jiangsu 210006,China)

机构地区：[1]南京中医药大学沭阳附属医院心内科,江苏宿迁223699 [2]南京医科大学附属南京第一医院心血管内科,江苏南京210006

出　　处：《国际检验医学杂志》2020年第24期2998-3002,3006,共6页International Journal of Laboratory Medicine

基　　金：江苏省自然科学基金青年科技人才专项项目(BK20162218)。

摘　　要：目的探讨高血压左心室肥厚患者血清可溶性基质溶素-2(ST-2)、半乳糖凝集素-3(galectin-3)的临床价值。方法收集研究对象(健康对照组、高血压左心室肥厚组、高血压非左心室肥厚组)的临床资料并检测血清ST-2、galectin-3水平。分析二者与心脏超声指标的相关性及对左心室肥厚的预测价值。结果健康对照组、高血压非左心室肥厚组、高血压左心室肥厚组收缩压(SBP)、舒张压(DBP)、三酰甘油(TG)、室间隔厚度(IVST)、左心室质量指数(LVMI)、左心室后壁厚度(LVPWT)、左心室射血分数(LVEF)、ST-2、galectin-3水平呈升高趋势,差异有统计学意义(P<0.05)。高血压左心室肥厚组血清ST2、galectin-3水平与LVMI、IVST、LVPWT呈正相关(P<0.05)。血清galectin-3、ST2预测左心室肥厚的曲线下面积(AUC)分别为0.868和0.890。结论高血压左心室肥厚患者血清ST2、galectin-3水平升高,二者与心脏超声指标相关,对左心室肥厚有一定预测潜能。Objective To investigate the clinical value of serum soluble matrix lysin-2(ST-2),galectin-3(galectin-3)in patients with hypertensive left ventricular hypertrophy.Methods The clinical data of subjects(healthy control group,hypertensive left ventricular hypertrophy group and hypertensive non left ventricular hypertrophy group)were collected,and serum ST-2 and galectin-3 levels were detected.The correlation between them and echocardiographic parameters and their predictive value for left ventricular hypertrophy were analyzed.Results Systolic pressure(SPB),diastolic pressure(DBP),triacylglycerol(TG),interventricular septum thickness(IVST),left ventricular mass index(LVMI),left ventricular posterior wall thickness(LVPWT),left ventricular ejection fractions(LVEF),ST-2 and galectin-3 increased in healthy control group,hypertensive non left ventricular hypertrophy group and hypertensive left ventricular hypertrophy group(P<0.05).Serum ST2 and galectin-3 levels were positively correlated with LVMI,IVST and LVPWT in hypertensive left ventricular hypertrophy group(P<0.05).The area under curve(AUC)of serum galectin-3 and ST2 were 0.868 and 0.890 in predicting left ventricular hypertrophy.Conclusion The serum ST2 and galectin-3 levels in patients with hypertension and left ventricular hypertrophy increase,and are correlated with echocardiographic indexes,which has certain predictive potential for left ventricular hypertrophy.

关 键 词：高血压 左心室肥厚 半乳糖凝集素-3 可溶性基质溶素-2 相关性 

分 类 号：R541.3[医药卫生—心血管疾病]