龟板调控BMSCs增殖、迁移和成骨分化及其抗骨质疏松症的研究进展  

Research progress of plastrum testudinis in regulating BMSCs’proliferation,migration and osteogenic differentiation and its anti-osteoporosis

作　　者：余翔[1] 任辉[1] 沈耿杨[1] 张鹏[2] 余富勇 尚奇[2] 汤凯 张志达[2] 招文华 梁德[1] 江晓兵[1,3] YU Xiang;REN Hui;SHEN Gengyang;ZHANG Peng;YU Fuyong;SHANG Qi;TANG Kai;ZHANG Zhida;ZHAO Wenhua;LIANG De;JIANG Xiaobing(Department of Spinal Surgery, First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou 510405, China;Guangzhou University of Chinese Medicine, Guangzhou 510405, China;Lingnan Medical Research Center of Guangzhou Univercity of Chinese Medicine, Guangzhou 510405, China)

机构地区：[1]广州中医药大学第一附属医院脊柱骨科,广东广州510405 [2]广州中医药大学,广东广州510405 [3]广州中医药大学岭南医学研究中心,广东广州510405

出　　处：《中国骨质疏松杂志》2020年第12期1847-1851,共5页Chinese Journal of Osteoporosis

基　　金：国家自然科学基金项目(81904225);广东省自然科学基金项目(2018A030310615);广东省教育厅基础研究及应用基础研究项目(2018KZDXM021);广州中医药大学第一临床医学院优秀博士论文培育项目(YB201702)。

摘　　要：近年来,中医药在抗骨质疏松症方面显示出独特优势。龟板被证实可通过miRNA及其靶基因、信号通路及相关因子调控BMSCs功能,从而抗骨质疏松症。本文对龟板调控BMSCs增殖、迁移和成骨分化及其抗骨质疏松症的研究进展进行综述,发现龟板体外可通过调节BMP-4、VDR、RARα、Id1等表达调控BMSCs增殖;可上调HGF/c-met轴、SDF-1/CXCR4轴促进BMSCs迁移;可通过调节成骨相关因子、miRNAs和信号通路调控BMSCs成骨分化。此外,龟板体内可有效抗PMOP、GIOP和SOP。本文旨在为中医药防治骨质疏松症提供相关参考。Recently,traditional Chinese medicine has shown unique advantages in anti-osteoporosis.Plastrum testudinis(PT)has been shown to affect the function of BMSCs through regulating osteoblast-related miRNAs’target genes,signaling pathways and related-factors,thereby achieving anti-osteoporosis effect.In this paper,we reviewed the effects of PT on the proliferation,migration,and osteogenic differentiation of BMSCs and its mechanism on anti-osteoporosis,providing references for anti-osteoporosis in traditional Chinese medicine.It have been found that PT can regulate BMSCs’proliferation through BMP-4,VDR,RARαand Id1 in vitro.PT can up-regulate the axis of HGF/c-met and SDF-1/CXCR4 to promote the migration of BMSCs.PT can regulate BMSCs’osteogenic differentiation through osteoblast-related factors,miRNAs and signaling pathways.In addition,PT can effectively resist PMOP,GIOP and SOP in vivo.This will provide references for anti-osteoporosis using traditional Chinese medicine.

关 键 词：中医药 龟板 骨质疏松症 干细胞 综述 

分 类 号：R259[医药卫生—中西医结合]