康柏西普联合阿托伐他汀治疗高血脂合并糖尿病性黄斑水肿的疗效观察  

Effect observation of conbercept combined with atorvastatin in the treatment of hyperlipidemia complicated with diabetic macular edema

作　　者：李彬彬[1] 胡莉群[1] 谭美华[1] 赖飞民 LI Binbin;HU Liqun;TAN Meihua;LAI Feimin(Department of Ophthalmology,Ganzhou City People′s Hospital in Jiangxi Province,Ganzhou,Jiangxi,341000)

机构地区：[1]江西省赣州市人民医院眼科,江西赣州341000

出　　处：《实用临床医药杂志》2020年第22期41-43,共3页Journal of Clinical Medicine in Practice

基　　金：江西省卫生计生委科技计划项目(20187237)。

摘　　要：目的观察康柏西普联合阿托伐他汀治疗高血脂合并糖尿病性黄斑水肿的临床疗效。方法选取94例2型糖尿病合并高血脂、非增殖性糖尿病视网膜病变、黄斑水肿及黄斑硬性渗出的患者,随机分为观察组和对照组,每组47例。对照组采用视网膜激光光凝治疗,观察组采用玻璃体腔注射康柏西普联合口服阿托伐他汀钙片治疗。比较2组患者治疗前和治疗6个月后的总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)水平,分析黄斑水肿、渗出及视力变化。结果治疗后,2组TC、TG、LDL-C水平较治疗前下降,HDL-C水平较治疗前升高,且观察组TC、TG、LDL-C水平低于对照组,HDL-C水平高于对照组,差异均有统计学意义(P <0.05)。治疗后,2组黄斑水肿、黄斑区硬性渗出及最佳矫正视力均较治疗前好转,且观察组优于对照组,差异均有统计学意义(P <0.05)。结论玻璃体腔注射康柏西普联合口服阿托伐他汀钙片能有效改善血脂代谢情况,减轻黄斑水肿和黄斑区硬性渗出,进而改善视力。Objective To observe the clinical effect of conbercept combined with atorvastatin in the treatment of hyperlipidemia complicated with diabetic macular edema.Methods Totally 94 type2 diabetes patients complicated with hyperlipidemia,non-proliferative diabetic retinopathy,macular edema,and macular hard exudation were selected and randomly divided into observation group and control group,with 47 cases in each group.The control group was treated with laser photocoagulation,while the observation group was treated with intravitreal injection of conbercept combined with oral taken atorvastatin calcium tablets.The levels of total cholesterol(TC),triglycerides(TG),highdensity lipoprotein cholesterol(HDL-C)and low-density lipoprotein cholesterol(LDL-C)before treatment and 6 months after treatment were compared between two groups,and changes in macular edema,exudation and visual acuity were analyzed.Results After treatment,the levels of TC,TG and LDL-C in both groups were significantly lower than those before treatment,while the HDL-C level was significantly higher than that before treatment,and the levels of TC,TG and LDL-C in the observation group were significantly lower than those in the control group,and the HDL-C level was significantly higher than that in the control group(P<0.05).After treatment,macular edema,macular hard exudation and best corrected visual acuity were improved in both groups,and these indexes in the observation group were significantly better than the control group(P<0.05).Conclusion Intravitreal injection of conbercept combined with oral taken atorvastatin calcium tablets can effectively improve blood lipid metabolism,reduce degrees of macular edema and macular hard exudation,and improve visual acuity.

关 键 词：2型糖尿病 高血脂 黄斑水肿 康柏西普 阿托伐他汀 疗效 

分 类 号：R972[医药卫生—药品] R58[医药卫生—药学]