ILC2在炎症性疾病中作用的研究进展  

Research progress of ILC2 in inflammatory diseases

作　　者：毋梦林 牛志国 曹旗(指导) 黄青松(指导) WU Meng-Lin;NIU Zhi-Guo;CAO Qi;HUANG Qing-Song(Henan Key Laboratory of Immunology and Targeted Drugs,School of Laboratory Medicine,Xinxiang Medical University,Xinxiang 453003,China)

机构地区：[1]新乡医学院医学检验学院,河南省免疫与靶向药物重点实验室,新乡453003

出　　处：《中国免疫学杂志》2020年第21期2672-2676,2680,共6页Chinese Journal of Immunology

基　　金：国家自然科学基金(81200506、81570624、81770721、U1804167);河南省自然科学基金重点项目(162300410210)资助。

摘　　要：2型固有淋巴细胞(ILC2)是最近发现的新型固有淋巴细胞群体,主要存在于肺、肠道、皮肤及黏膜组织,在IL-25和IL-33等刺激下能够产生IL-4、IL-5、IL-9和IL-13等Th2型细胞因子,在自身免疫病、抗感染和体内免疫平衡中发挥重要作用。本文综述了ILC2在炎症性疾病发展过程中的免疫学特性及其发挥的作用,及脏器局部微环境改变对ILC2的影响,为进一步了解ILC2参与的炎症性疾病发病机制及相关治疗提供理论依据。Type 2 innate lymphoid cell(ILC2)are a newly discovered new type of innate lymphocytes,which mainly found in lungs,intestines,skin and mucosal tissues.Under the stimulation of IL-25 and IL-33,they can produce Th2 cytokines such as IL-4,IL-5,IL-9 and IL-13,which play an important role in autoimmune diseases,anti-infection and immune balance in vivo.This article reviews the immunological characteristics and role of ILC2 in development of inflammatory diseases,as well as influence of local organ microenvironment changes on ILC2,so as to provide theoretical basis for further understanding of the pathogenesis and related treatment of ILC2 in inflammatory diseases.

关 键 词：2型固有淋巴细胞 炎症 TH2型细胞因子 

分 类 号：R392.9[医药卫生—免疫学]