不同治疗方法对老年脓毒症休克患者的炎性介质及其免疫功能的影响  

Effects of different treatments on inflammatory mediators and immune function in elderly patients with septic shock

作　　者：赵立新[1] 王琳[1] 于四方 侯俊名 李雪松[1] 王建光 ZHAO Lixin;WANG Lin;YU Sifang(The Second Department of Intensive Care Union Tangshan Gongren Hospital,Tangshan 063000,China)

机构地区：[1]河北省唐山工人医院重症医学二科,河北唐山063000 [2]唐山中心医院急诊ICU [3]唐山工人医院康复医院重症监护

出　　处：《华北理工大学学报（医学版）》2021年第1期19-22,共4页Journal of North China University of Science and Technology：Health Sciences Edition

基　　金：河北省卫生厅青年科技课题(编号:20201506)。

摘　　要：目的观察不同治疗方法对老年脓毒症休克患者的炎性介质及其对免疫功能的影响。方法选取2016年9月~2019年5月进入我院接受治疗的48例老年脓毒症休克确诊患者为研究对象。根据治疗方式不同,将其分成对照组、乌司他丁组和治疗组,比较三组患者治疗后早期不同时间点的炎性指标及免疫功能指标变化情况。结果与对照组相比,乌司他丁组和治疗组患者治疗后不同时间段降钙素原(PCT)、超敏C反应蛋白(hs-CRP)与血浆氨基末端脑钠肽前体(NT-pro BNP)差异有统计学意义;且在第3天和第7天,治疗组PCT、hs-CRP与NT-pro BNP较乌司他丁组明显下降,差异有统计学意义(P<0.05)。与对照组相比,乌司他丁组和治疗组治疗后3个时间点的各项免疫指标均更优,且在第3天及第7天CD4和CD8、CD4/CD8计数治疗组优于乌司他丁组,差异有统计学意义(P<0.05)。结论乌司他丁联合胸腺肽α1对老年脓毒症休克的炎性因子及免疫功能有一定的调节作用。Objective To observe the effects of different treatments on inflammatory media and immune function in elderly sepsis shock patients.Methods The study subjects were 48 patients with elderly sepsis shock who were treated in the hospital from September 2016 to May 2019.According to different treatment methods,they were divided into control groups,ulinastatin groups and treatment groups,compared to the three groups of patients with different points of time after treatment and changes in immune function indicators.Results Compared to the control group,the differences between the ulinastatin group and the treatment group patients in the various inflammatory-related indicators Procalcitonin(PCT),hypersensitivity C reaction protein(hs-CRP)and the plasma amino end brain sodium peptide precursor(NT-pro BNP)were statistically significant;The statin group decreased significantly,the effect was obvious,the difference was statistically significant(P<0.05),and compared with the control group,the ulinastatin group and the treatment group treated the three different points of time of the immune indicators are better,and on the 3rd and 7th days CD4 and CD8,CD4/CD8 counting treatment group was better than the ulinastatin group,the difference was statistically significant(P<0.05).Conclusion Ulinastatin combined with thymosinα1 has a certain regulatory effect on inflammatory factors and immune function in elderly sepsis shock.

关 键 词：脓毒症休克 免疫功能 乌司他丁 炎性介质 

分 类 号：R459.7[医药卫生—急诊医学]