肥胖在射血分数保留的心力衰竭研究中的进展  

Research progress on obesity in heart failure with preserved ejection fraction

作　　者：陈文文 张烁[1] CHEN Wen-wen;ZHANG Shuo(Department of Cardiology,Second Affiliated Hospital of Harbin Medical University,Harbin,Heilongjiang,150001,China)

机构地区：[1]哈尔滨医科大学附属第二医院心内科,黑龙江哈尔滨150001

出　　处：《心血管康复医学杂志》2020年第6期733-735,共3页Chinese Journal of Cardiovascular Rehabilitation Medicine

摘　　要：近年来对射血分数保留的心力衰竭(HFpEF)的理解已经从舒张功能障碍转变为一系列导致左心室充盈压力升高和运动不耐受的生理损伤,故防治的重点已转向生活方式相关因素。最近的研究表明,肥胖是预防和管理HFpEF患者潜在可改变的目标之一。本综述讨论了新出现的流行病学、机制和临床证据,还总结了发展运动训练和减肥作为管理HFpEF的有效治疗策略的现有证据和不足。In recent years,understanding of heart failure with preserved ejection fraction(HFpEF)has evolved from diastolic dysfunction to a series of physiological impairments that lead to increased left ventricular filling pressure and exercise intolerance.Therefore,focus of prevention and treatment has transformed to related factors of lifestyle.Recent researches indicated that obesity was one of potential changeable targets for prevention and management of HFpEF patients.The present review discusses novel epidemiology,mechanisms and clinical evidence,and summarizes current evidence and disadvantages for developing exercise training and losing weight as effective therapeutic strategies of HFpEF management.

关 键 词：心力衰竭 肥胖症 运动疗法 

分 类 号：R541.610.9[医药卫生—心血管疾病]