部分血浆置换联合双重血浆分子吸附对慢加急性肝衰竭患者短期生存率的影响  

Influence of double plasma molecular adsorption system combined with partial plasma exchange on short⁃term survival rate of patients with acute⁃on⁃chronic liver failure

作　　者：陈黎[1] 林杨 刘旭东[1] 刘容 唐艳芳[1] 刘丽[1] CHEN Li;LIN Yang;LIU Xudong;LIU Rong;TANG Yanfang;LIU Li(Department of Liver Disease,Ruikang Hospital Affiliated to Guangxi University of Chinese Medicine,Nanning 530011,China)

机构地区：[1]广西中医药大学附属瑞康医院肝病科,南宁530011

出　　处：《实用医学杂志》2020年第23期3237-3240,共4页The Journal of Practical Medicine

基　　金：2019年中医药传承与创新人才培养平台建设项目(编号:国中医药人教函〔2019〕41号)。

摘　　要：目的探讨部分血浆置换联合双重血浆分子吸附与血浆置换两种人工肝治疗方案对慢加急性肝衰竭患者短期生存率的影响。方法回顾性收集53例接受人工肝治疗的慢加急性肝衰竭住院患者,采取双重血浆分子吸附联合部分血浆置换模式30例,采取血浆置换模式23例。比较两组患者治疗前后相关血清生化学指标及4、12周生存率,并对慢加急性肝衰竭患者部分临床预后影响因素进行单因素分析。结果两组治疗后肝功能均有改善,差异有统计学意义(P<0.05),两组患者4周累积生存率分别为86.96%及96.67%;12周随访累积生存率分别为86.67%及69.56%,两组间差异无统计学意义(P>0.05)。结论两种模式的人工肝均有效改善慢加急性肝衰竭患者相关生化指标,两者对慢加急性肝衰竭患者短期生存率影响并无明显差异。Objective To investigate the different effects of partial plasma exchange combined with dual plasma molecular adsorption and pure plasma exchange on short⁃term survival rate of patients with acute⁃on⁃chronic liver failure(ACLF).Methods Data of 53 hospitalized patients with ACLF who received artificial liver therapy including 30 treated with dual plasma molecular adsorption combined with partial plasma exchange and 23 with simple plasma exchange,were retrospectively analyzed.Related serum biochemical indexes and survival rates at the 4th and 12th week were compared between the two groups before and after the treatment,and clinical prognostic factors of ACLF patients were analyzed by univariate analysis.Results Liver function were improved in both groups after the treatment,and the difference was statistically significant(P<0.05).Cumulative survival rate of the two groups at the 4th week was 86.96%and 96.67%respectively and the follow⁃up cumulative survival rate at the 12th week was 86.67%and 69.56%respectively,showing no statistical significance(P>0.05).Conclusion Dual plasma molecular adsorption combined with partial plasma exchange and pure plasma exchange effectively improve the relevant biochemical indexes of patients with ACLF,but they play no significant role in short⁃term survival rate.

关 键 词：肝 人工肝 双重血浆分子吸附 部分血浆置换 慢加急性肝衰竭 短期生存率 

分 类 号：R459.5[医药卫生—治疗学]