细胞膜色谱法改进及应用进展  

Improvement and application of cell membrane chromatography

作　　者：李亚男 王松 丛海林 于冰 Li Ya’nan;Wang Song;Cong Hailin;Yu Bing(Institute of Biomedical Materials and Engineering,College of Chemistry and Chemical Engineering,Qingdao University,Affiliated Hospital of Qingdao University,Qingdao 266071,China;State Key Laboratory of Bio-Fibers and Eco-Textiles,College of Materials Science and Engineering,Qingdao University,Qingdao 266071,China)

机构地区：[1]青岛大学生物医用材料与工程研究院,青岛大学化学化工学院,青岛大学附属医院,青岛266071 [2]生物多糖纤维成形与生态纺织国家重点实验室,青岛大学材料科学与工程学院,青岛266071

出　　处：《分析仪器》2020年第6期7-16,共10页Analytical Instrumentation

基　　金：国家自然科学基金(21675091,21874078)。

摘　　要：细胞膜色谱(CMC)是在生物学和色谱学的基础上,研究流动相中有效成分与受体相互作用规律的方法。由于稳定性高、检测快速和灵敏度高等特点,细胞膜色谱法已被广泛应用于天然产物中的活性成分筛选,以及药物与受体之间相互作用方式。大量研究表明,细胞膜色谱对于药物的分离和筛选具有重要意义。本文针对近几年对于细胞膜色谱技术的改进和相关应用分别综述了其研究进展。Cell Membrane Chromatography(CMC)is a method for studying the interaction between active components and receptors in mobile phase.With high stability,rapid detection and high sensitivity,cell membrane chromatography has been widely used in the screening of active ingredients in natural products and the interaction between drugs and receptors.A large number of study results show that cell membrane chromatography is of great significance for the separation and screening of drugs.In this paper,the improvement of cell membrane chromatography technology and the research progress of related applications in recent years are reviewed.

关 键 词：细胞膜色谱 中药活性成分 筛选 色谱 

分 类 号：O657.7[理学—分析化学]