针药并用治疗老年H型阴虚阳亢型高血压病疗效观察  

Efficacy Observation of Acupuncture Combined with Medication for Elderly H-type Hypertension of Yin Deficiency and Yang Hyperactivity Pattern

作　　者：李玉环[1] 商庆新[1] 韩云 齐向荣[2] 李文秋 LI Yu-huan;SHANG Qing-xin;HAN Yun;QI Xiang-rong;LI Wen-qiu(Shandong University of Traditional Chinese Medicine,Jinan 250014,China;Shandong Jinan No.2 People’s Hospital,Jinan 250014,China)

机构地区：[1]山东中医药大学,济南250014 [2]济南市第二人民医院,济南250014

出　　处：《上海针灸杂志》2020年第12期1499-1504,共6页Shanghai Journal of Acupuncture and Moxibustion

基　　金：山东省重点研发计划项目(2016GSF202027)。

摘　　要：目的观察针药并用治疗老年H型高血压病的临床疗效及其对炎性因子指标及血管内皮功能的影响。方法将104例老年H型高血压病(阴虚阳亢型)患者随机分为治疗组和对照组,每组52例。治疗组采用针刺配合药物治疗,对照组采用单纯药物治疗。观察两组治疗前后各项症状(头晕、头痛、五心烦热)评分、炎性因子[肿瘤坏死因子-α(TNF-α)、超敏C反应蛋白(hs-CRP)]指标、血压(收缩压和舒张压)及血同型半胱氨酸(Hcy)、一氧化氮(NO)、内皮素-1(ET-1)水平的变化情况,并比较两组临床疗效及不良反应发生率。结果两组治疗后各项症状评分、炎性因子指标、血压及Hcy、NO、ET-1水平与同组治疗前比较差异均具有统计学意义(P<0.05)。治疗组治疗后各项症状评分、炎性因子指标、血压及Hcy、NO、ET-1水平与对照组比较差异均具有统计学意义(P<0.05)。治疗组总有效率和不良反应发生率分别为94.2%和25.0%,对照组分别为75.0%和21.2%,两组总有效率比较差异具有统计学意义(P<0.05);两组不良反应发生率比较差异无统计学意义(P>0.05)。结论针药并用是一种治疗老年H型阴虚阳亢型高血压病的有效方法,能有效减轻炎症反应,调节血管内皮功能。Objective To observe the clinical efficacy of acupuncture plus medication in treating elderly H-type hypertension and its effects on the inflammatory factor indexes and vascular epithelial function.Method A total of 104 elderly patients with H-type hypertension(yin deficiency and yang hyperactivity pattern)were randomized into a treatment group and a control group,with 52 cases in each group.The treatment group was intervened by acupuncture plus medication,while the control group was treated with medication alone.Before and after treatment,the symptom scores(dizziness,headache and feverish sensation in the five centers),inflammatory factor indexes[tumor necrosis factor(TNF)-αand high-sensitivity C-reactive protein(hs-CRP)],blood pressure(systolic pressure and diastolic pressure),blood homocysteine(Hcy),NO,endothelin-1(ET-1)were observed in the two groups.The clinical efficacy and adverse reaction rate were compared between the two groups.Result The symptom scores and the levels of inflammatory factor indexes,blood pressure,Hcy,NO and ET-1 changed significantly after treatment in both groups(P<0.05).After intervention,the symptom scores and the levels of inflammatory factor indexes,blood pressure,Hcy,NO and ET-1 in the treatment group were significantly different from those in the control group(P<0.05).The total effective rate was 94.2%and the adverse reaction rate was 25.0%in the treatment group,versus 75.0%and 21.2%in the control group.There was a significant difference in the total effective rate between the two groups(P<0.05),while the between-group difference in the adverse reaction rate was statistically insignificant(P>0.05).Conclusion Acupuncture combined with medication is an effective approach for elderly H-type hypertension of yin deficiency and yang hyperactivity pattern,as it can effectively reduce inflammatory reactions and regulate vascular epithelial function.

关 键 词：针刺疗法 高血压 肿瘤坏死因子-α 超敏C反应蛋白 血同型半胱氨酸 阴虚阳亢 

分 类 号：R246.1[医药卫生—针灸推拿学]