银甲丸加减联合西药治疗慢性盆腔炎湿热瘀结证的临床疗效  

Clinical efficacy of modified Yinjiapill combined western medicine in the treatment of chronic pelvic inflammation with dampness and heat stasis

作　　者：张爱华[1] 赵嘉梅[1] ZHANG Aihua;ZHAO Jiamei(Affiliated Hospital of Henan Traditional Chinese Medicine Institute,Zhengzhou 450003,Henan)

机构地区：[1]河南省中医药研究院附属医院,河南郑州450003

出　　处：《菏泽医学专科学校学报》2020年第4期42-44,共3页Journal of Heze Medical College

摘　　要：目的探讨银甲丸加减联合西药治疗慢性盆腔炎湿热瘀结证的临床疗效。方法将90例患者随机分为对照组和观察组,每组45例。对照组口服左氧氟沙星联合甲硝唑,观察组在对照组治疗基础上口服银甲丸加减,疗程均为4周。观察治疗前后患者的血液流变学指标(全血黏度、全血比黏度、纤维蛋白原),促炎因子[白细胞介素-1β(IL-1β)、粒-巨核细胞集落刺激因子(GMCSF)、白细胞介素-6(IL-6)],抑炎性因子[白细胞介素-4(IL-4)、转化生长因子-β1(TGF-β1)、白细胞介素-10(IL-10)],比较两组临床疗效。结果观察组总有效率高于对照组(P<0.05)。与对照组治疗后比较,观察组全血黏度、全血比黏度、纤维蛋白原、血清IL-1β、GM-CSF、IL-6明显降低(P<0.05),IL-4、TGF-β1、IL-10含量明显升高(P<0.05)。结论银甲丸加减联合西药可有效改善慢性盆腔炎湿热瘀结证患者的血液流变学和血清炎性因子指标。Objective To investigate the clinical effect of modified Yinjiapill combined western medicine in the treatment of chronic pelvic inflammation with dampness and heat stasis.Methods 90 patients were randomly divided into the control group and the observation group,45 cases in each group.The control group was taken levofloxacin and metronidazole,while the observation group was given modified Yinjiapill on the basis of the control group,treatment last⁃ing for 4 weeks.Hemorheology indexes(whole blood viscosity,whole blood ratio viscosity,fibrinogen),proinflammatory factor[interleukin-1β(IL-1β),grain-megakaryocyte colony stimulating factor(GM-CSF),interleukin 6(IL-6)],inhibit⁃ing inflammatory factor[interleukin 6(IL-6),transforming growth factor-β1(TGF-β1),interleukin 10(IL-10)]of the two groups were observed before and after treatment,and the clinical efficacy of the two groups were compared.Re⁃sults Total effective rate in the observation group was higher than that in the control group(P<0.05).Compared with the control group after treatment,whole blood viscosity,whole blood ratio viscosity,fibrinogen,IL-1β,GM-CSF,IL-6 sig⁃nificantly decreased in the observation group(P<0.05);levels of IL-8,TGF-β1 and IL-10 significantly elevated(P<0.05).Conclusion Modified Yinjiapill combined western medicine can effectively improve hemorheology and serum inflammatory factors in patients with chronic pelvic inflammation with dampness and heat stasis.

关 键 词：银甲丸加减 慢性盆腔炎 湿热瘀结证 

分 类 号：R711[医药卫生—妇产科学]