生长抑素治疗肠梗阻临床疗效评价  

Efficacy of Somatostatin in the Treatment of Intestinal Obstruction

作　　者：黄乘龙 程雨曦 魏正强[1] 吴晓醒[1] 王浩宇 张伟[1] 毛冰朗[1] 黎晖[1] 徐维[1] 闵江[1] 钱昆[1] HUANG Chenglong;CHENG Yuxi;WEI Zhengqiang;WU Xiaoxing;WANG Haoyu;ZHANG Wei;MAO Binglang;LI Hui;XU Wei;MIN Jiang;QIAN Kun(Department of Castrointestinal Surgery,The Fis Afliated Hospial of Chongying Medicnl University,Chongying,China 40016;Department of beneral Surgery,Tongnan District People's Hospital,Chongqing,China 402660)

机构地区：[1]重庆医科大学附属第一医院胃肠外科,重庆400016 [2]重庆市潼南区人民医院普通外科,重庆402660

出　　处：《中国药业》2020年第24期55-57,共3页China Pharmaceuticals

基　　金：重庆市重大疾病防治技术攻关项目[2019ZX003]。

摘　　要：目的探讨生长抑素治疗肠梗阻的临床疗效。方法选取重庆医科大学附属第一医院2016年至2017年收治的肠梗阻患者134例,随机分为对照组(78例)和试验组(56例)。两组患者均予禁食禁饮,胃肠减压,纠正酸碱和电解质紊乱,营养支持等基础治疗;试验组患者加用注射用生长抑素6mg静脉泵注,两组均持续治疗3d。结果试验组患者腹胀缓解率、腹痛缓解率分别为75.00%和83.93%,显著高于对照组的52.56%和67.95%(P<0.05),治疗3d内排气率无显著差异(46.43%比41.38%,P>0.05);试验组患者胃肠减压量、小肠梗阻患者胃肠减压量均显著小于对照组,血钠、血钾水平及渗透压均显著高于对照组(P<0.01);试验组小肠梗阻患者手术率显著低于对照组(25.00%比41.03%,P<0.01)。结论生长抑素可缓解肠梗阻临床症状,减少胃肠减压量,纠正低钠、低钾血症及低渗透压脱水状态。对小肠梗阻患者使用生长抑素可降低手术率,对结直肠梗阻患者需慎用或不用。Objective To investigate the clinicalefficacy of somatostatin in the treatment of patients with intestinal obstruction.Methods Totlly 134 patients with intestinal obstnuction admitted to The First Affiliated Hospital of Chongqing Medtical University from2016 to 2017 were selected and randomly divided into the control group(78 cases)and the experim ntal group(56 cases).The patients in the two groups were given basic treatment such as fasting,gastrointestinal decompression,correctin:acid-base and electrolyte disor-ders,and nutritional support,on this basis,the patients in the experimental group were injected 6 mg Somatostatin for lInjection.Bothgroups were continuously trealed for 3 d.Results The remission rate of abdominal distension and abdominal pain in the experimentalgroup were 75.00%and 83.93%,which were significantly higher than 52.56%and 67.95%in the control group(P<0.05).Therewas no significant difference in the exhaust within 3 d afer treatment(46.43%ts.41.38%,P>0.05).The gastrointestinal decom-pression of patients and the gastrointestinaldecompression of patients with small-bowel obstruction in the experimental group were sig-nificantly less than those in the control group,the levels of blood sodium and potassium and osmotic pressure in the experimental groupwere significantly lower than those in the control group(P<0.01).The operation rate of patients with small-bowel obstruction in theexperimental group was significantly lower than that in the control group(25.00%os.41.03%,P<0.01).Conclusion Somatostatincan relieve the clinicalsympltoms of intestinal obstruction,reduce gastrointestinal decompression,correct hyponatrenia,hypokalenia andhypotonic dehydration.The application of sonatostatin in patients with small-bowel obstruction can reduce the operation rae.Iht is re-ommended to use somatostatin cautiously or not in patients with colorectal obstruction.

关 键 词：生长抑素 肠梗阻 临床疗效 小肠梗阻 结直肠梗阻 

分 类 号：R969.4[医药卫生—药理学] R975.7[医药卫生—药学]