小剂量阿托伐他汀联合美托洛尔治疗心力衰竭临床研究  

Clinical Study of Low-Dose Atorvastatin Combined with Metoprolol in the Treatment of Heart Failure

作　　者：陈红云[1] 李清涛[2] 郭研铎 吕娜 CHEN Hongyun;LI Qingtao;GUO Yanduo;LYU Na(Nanpi People's Hospital,Cangzhou,Hebei,China 061500;Hebei Children's Hospital,Shijiaz uang,Hebei,China 050000)

机构地区：[1]河北省沧州市南皮县人民医院,河北沧州061500 [2]河北省儿童医院,河北石家庄050000

出　　处：《中国药业》2020年第24期67-69,共3页China Pharmaceuticals

基　　金：河北省医学科学研究重点课题[20180628]。

摘　　要：目的探讨小剂量阿托伐他汀联合美托洛尔治疗心力衰竭(简称心衰)的临床疗效及对患者血浆同型半胱氨酸(HCY)、氨基末端脑钠肽前体(NT-proBNP)、血清瘦素(Leptin)水平的影响。方法选取南皮县人民医院2017年4月至2019年4月收治的心衰患者90例,随机分为观察组和对照组,各45例。两组患者均予基础治疗及口服酒石酸美托洛尔片,观察组患者加服小剂量阿托伐他汀钙,均持续治疗3个月。结果观察组总有效率为91.11%,显著高于对照组的73.33%(P<0.05);治疗后,观察组患者的左室射血分数(LVEF)显著高于对照组,左室收缩末期内径(LVESd)、左室舒张末期内径(LVEDd)均显著短于对照组,QT间期离散度(QTd)均显著小于对照组,HCY,NT-proBNP、Leptin水平均显著低于对照组(P<0.05);观察组与对照组不良反应发生率相当(15.56%比8.89%,χ2=0.932,P>0.05)。结论小剂量阿托伐他汀联合美托洛尔治疗心衰,能提高心功能,降低炎性因子水平。Objective To investigate the clinical efficacy of low-dose atorvastatin calcium combined with metoprolol in the treatment of patients with heart failure and is effect on plasma homocysteine(HCY),N-terminal pro brain natriuetic peptide(NT-poBNP)andserum leptin(Leptin).MethodsTotally 90 patients with heart failure admitted to our hospital from Apil 2017 to Apil 2019 were se-lected and randomly divided into the observation group and the control group,45 cases in each group.The patients in the two groupswere given basic treatment and Metoprolol Tartrate Tablets orally,on this basis,the patients in the observation group were treated withlow-dose aforvastatin calcium.Both groups were continously treated for 3 months.ResultsThe total effective rate of the observationgroup was 91.11%,which was significantly higher than 73.33%of the control group(P<0.05).After treatment,the left ventricular e-jection fraction(LVEF)in the observation group was significantly higher than that in the control group,the left ventricular end systolicdiameter(LVESd)and left ventricular end diasltolic diameter(LVEDd)in the observation group were significantly shorter than those.inthe control group(P<0.05).the QT interval dispersion(QTd)in the observation group was significantly lower than that in the controlgroup(P<0.05),the levels of HCY,NT-proBNP and leptin in the observation group were significanly lower than those in the con-trol group(P<0.05).The incidence of adverse reactions in the observation group was similar to that in the control group(15.56%vs.8.89%,x^2=0.932,P>0.05).Conclusion low-dose atorvastatin calcium combined with metoprolol in the treatment of patients withheart failure can improve cardiac function and reduce the level of inflammatory factors.

关 键 词：心力衰竭 阿托伐他汀 美托洛尔 心功能 同型半胱氨酸 氨基末端脑钠肽前体 血清瘦素 

分 类 号：R969.4[医药卫生—药理学] R972.1[医药卫生—药学]