牙髓血运重建术联合二联抗生素糊剂治疗年轻恒牙牙髓坏死临床评价  

Clinical Evaluation of Pulp Revascularization Combined with Dual Antibiotic Paste in the Treatment of Pulp Necrosis in Young Permanent Teeth

作　　者：王菲菲[1] 王洁[2] 张丽杰[1] 樊世峰 刘丝雨 WANG Feifei;WANG Jie;ZHANG Lijie;FAN Shifeng;LIU Siyu(The Third Hospital of Hebei Medical University,Shijiazhuang,Hebei,China 050000;Stomatologica Hospital of Hebei Medical University,Shijiazhuang,Hebei,China 050000;Tangshan People's Hospital,Tangshan,Hebei,China 063000)

机构地区：[1]河北医科大学第三医院,河北石家庄050000 [2]河北医科大学口腔医院,河北石家庄050000 [3]河北省唐山市人民医院,河北唐山063000

出　　处：《中国药业》2020年第24期76-79,共4页China Pharmaceuticals

基　　金：河北省医学科学研究重点课题[20160603]。

摘　　要：目的探讨牙髓血运重建术联合二联抗生素糊剂(DAP)治疗年轻恒牙牙髓坏死的疗效。方法选取医院2017年3月至2019年3月收治的年轻恒牙牙髓坏死患者94例,按非随机临床同期对照组研究及患者自愿原则分为观察组(50例,50颗患牙)与对照组(44例,44颗患牙),分别实施牙髓血运重建术联合DAP,牙髓血运重建术联合三联抗生素糊剂(TAP)。结果两组患者术后1个月总有效率无显著差异(P>0.05);术后6个月,观察组患者龈沟液碱性成纤维细胞生长因子(bFGF)、血管内皮生长因子(VEGF)水平均显著高于对照组,牙根长度、牙根管壁厚度与对照组相当(P>0.05),两组患者患牙骨质样组织沉积率及根折、根管内感染发生率相当(P>0.05);观察组患者牙体变色率显著低于对照组(P<0.05)。结论与TAP作为根管消毒剂相比,牙髓血运重建术联合DAP治疗年轻恒牙牙髓坏死,可有效减少牙体变色。Objective To investigate the efficacy of pulp revascularization combined wih dual antibiotic paste(DAP)in the treatment ofpulp necrosis in young permanent teeth.Methods Totally 94 patients with pulp necrosis in young permanent teeth admitted to our hos-pital from March 2017 to March 2019 were selected and divided into the observation group(50 cases,50 affected teeth)and the con-trol group(44 cases,44 affected teeth)according to the concurrent controlled non-randonized clinical trail and the voluntary principleof patients.The patients in the observation group were treated with pulp revasculariation combined wih DAP,while the paients in thecontrol group were treated with pulp revascularization combined with triple antibiotic paste(TAP).Results One month after operation,there was no significant difference in the total effective rate between the two groups(P>0.05).Six months afier operation,the levelsof basic fibroblast growth factor(bFCF)and vascular endothelial growth factor(VECF)in gingival crevicular fluid of patients in the ob-servation group were significantly higher than those in the control group(P<0.05),while the dental mot length,rowt canal wall thic.l-ness of patients in the observation group were similar to those in the control group(P>0.05),the incidence of cementoid tissue deposition,root fracture and root canal infection in the two groups were similar(P>0.05).The discoloration rale of toth in the olservwa-tion group was significantly lower than that in the control group(P<0.05).Conclusion Compared with TAP as a mot canal disinfec-tant,pulp revascularization combined with DAP in the treatment of pulp necrosis in young permanent teeth can efectively reduce tothdiscoloration.

关 键 词：牙髓血运重建术 二联抗生素糊剂 年轻恒牙 牙髓坏死 

分 类 号：R969.4[医药卫生—药理学] R988.2[医药卫生—药学]