子痫前期患者血浆preptin水平检测及临床意义研究  

Study on the detection of plasma preptin in patients with preeclampsia and its clinical significance

作　　者：彭琳[1] 肖正华[1] 商琳 李自琼[2] PENG Lin;XIAO Zhenghua;SHANG Lin;LI Ziqiong(Department of Obstetrics,Yongchuan Hospital,Chongqing Medical University,Chongqing 402160,China;Department of Infectious Diseases,the First Affiliated Hospital of Chongqing Medical University,Chongqing 400040,China)

机构地区：[1]重庆医科大学附属永川医院产科,重庆402160 [2]重庆医科大学附属第一医院感染科,重庆400040

出　　处：《现代医药卫生》2020年第24期3945-3948,共4页Journal of Modern Medicine & Health

基　　金：重庆医科大学附属第一医院护理科研项目(HJJ-201522)。

摘　　要：目的研究子痫前期(PE)患者血浆中preptin分子的表达水平,并分析其与血压、血脂等指标的关系及临床意义。方法选取重庆医科大学附属永川医院产检并诊断为PE的患者57例作为PE组,选取该院进行产检的正常孕妇60例作为健康组。2组研究对象均监测24 h动态血压、血浆preptin、血脂水平,分别分析血浆preptin水平与血压和血脂的相关性,并采用回归分析评估preptin对PE发生的影响。结果与健康组比较,PE组患者的血压、总胆固醇水平升高,而血浆preptin水平显著降低,差异均有统计学意义(P<0.05)。血浆preptin水平与日间平均收缩压、日间平均舒张压、总胆固醇呈负相关(P<0.05)。回归分析显示,血浆preptin可能是PE发生的保护性因素(OR<1,P<0.05)。结论PE患者血浆中preptin水平显著低于正常孕妇,且与日间平均收缩压、日间平均舒张压、总胆固醇具有相关性,血浆preptin可能在PE的发病中具有一定作用。Objective To study the expression level of preptin molecule in the plasma of patients with preeclampsia(PE),and analyze its relationship with blood pressure,blood lipid and other indicators and its clinical significance.Methods Fifty-seven patients who were diagnosed as PE during obstetrics at Yongchuan Hospital of Chongqing Medical University were selected as the PE group,and 60 normal pregnant women who underwent obstetrics at the hospital were selected as the healthy group.Both groups of subjects monitored 24 h ambulatory blood pressure,plasma preptin and blood lipid levels,and analyzed the correlation between plasma preptin level and blood pressure and blood lipids.Regression analysis was used to evaluate the effect of preptin on the occurrence of PE.Results Compared with the healthy group,the blood pressure and total cholesterol levels of the PE group were increased,while the plasma preptin level was significantly decreased,and the difference was statistically significant(P<0.05).The plasma preptin level was negatively correlated with the average daytime systolic blood pressure,the average daytime diastolic blood pressure,and total cholesterol(P<0.05).Regression analysis showed that plasma preptin may be a protective factor for PE(OR<1,P<0.05).Conclusion The level of plasma preptin in PE patients is significantly lower than that of normal pregnant women,and is correlated with the average daytime systolic blood pressure,the average daytime diastolic blood pressure,and total cholesterol.Plasma preptin may play a role in the pathogenesis of PE.

关 键 词：子痫前期 Preptin分子 血压 血脂 总胆固醇 

分 类 号：R714.25[医药卫生—妇产科学]