特比萘芬在皮下及深部真菌感染中的临床应用  

Clinical application of terbinafine in the treatment of subcutaneous and deep mycosis

作　　者：朱红梅[1] 温海[1] ZHU Hong-mei;WEN Hai(Department of dermatology andvenerology, Changzheng Hosp ital, Shanghai 200003,China)

机构地区：[1]上海长征医院皮肤科,上海200003

出　　处：《中国真菌学杂志》2020年第6期374-377,共4页Chinese Journal of Mycology

摘　　要：特比萘芬丙烯胺类抗真菌药物,对丝状真菌、双相真菌及酵母菌具有广谱抗真菌活性。除了在皮肤癣菌感染中用作一线治疗用药,特比萘芬在皮肤皮下及深部真菌感染中,也有较为广泛的临床应用,是一种安全有效的治疗药物。Terbinafine is an active allylamine antifungal agent with a mechanism of inhibiting squalene epoxidase in the fungal cell membrane.Its spectrum of in vitro fungicidal activity includes a broad range of dermatophyte,filamentous,dimorphic fungi,and some yeast species.Terbinafine had been widely used as the first-line treatment for superficial dermatophyte infection.In nearly two decades,terbinafine also had been proved to be highly effective and safe for a variety of subcutaneous and deep fungal infections,either in monotherapy or in combination therapy.

关 键 词：特比萘芬 皮肤皮下真菌感染 深部真菌感染 

分 类 号：R978.5[医药卫生—药品] R.519[医药卫生—药学]