国产雷帕霉素洗脱支架治疗椎动脉狭窄临床研究  

Domestic rapamycin-eluting stent for the treatment of vertebral artery stenosis:a clinical study

作　　者：黄志志[1] 廖宝 梁柯[1] 李绍发[1] 李登星 HUANG Zhizhi;LIAO Bao;LIANG Ke;LI Shaofa;LI Dengxing(Department of Neurology,Baise Municipal People’s Hospital,Baise City,Guangxi Zhuang Autonomous Region 533000,China)

机构地区：[1]百色市人民医院神经内科,广西533000

出　　处：《介入放射学杂志》2020年第11期1072-1074,共3页Journal of Interventional Radiology

基　　金：广西百色市科学研究与技术开发计划项目(百科计20110526)。

摘　　要：目的评价国产雷帕霉素洗脱支架治疗椎动脉狭窄的安全性、有效性及术后支架内再狭窄。方法回顾性分析2013年5月至2018年12月百色市人民医院采用血管内支架成形术治疗的138例症状性椎动脉起始部狭窄患者临床资料。其中75例接受国产雷帕霉素洗脱支架治疗(药物支架组),63例接受金属裸支架治疗(裸支架组)。观察手术成功率、围手术期并发症及术后支架内再狭窄发生率。结果两组手术成功率均为100%。无围手术期并发症发生。术后随访1~18个月,平均15.3个月。药物支架组、裸支架组术后支架内再狭窄率分别为12.0%(9/75)、28.6%(18/63)例,差异有显著统计学意义(P=0.015)。结论国产雷帕霉素洗脱支架治疗椎动脉狭窄安全有效,可有效降低术后支架内再狭窄。Objective To evaluate the safety and efficacy of domestic rapamycin-eluting stent in treating vertebral artery stenosis,and to discuss the occurrence of postoperative in-stent restenosis.Methods The clinical data of 138 patients with symptomatic vertebral artery stenosis,who were admitted to the Baise Municipal People’s Hospital of China to receive endovascular stent angioplasty during the period from May 2013 to December 2018,were retrospectively analyzed.Of the 138 patients,75 received domestic rapamycin-eluting stent treatment(drug-eluting stent group,DES group)and 63 received bare-metal stent treatment(bare-metal stent group).The surgical success rate,perioperative complications and incidence of postoperative in-stent restenosis were analyzed.Results The surgical success rate was 100%in both two groups.No perioperative complications occurred.The patients were followed up for 1-18 months with a mean of 15.3 months.The postoperative in-stent restenosis incidences in the DES group and the bare-metal stent group were12.0%(9/75)and 28.6%(18/63)respectively,the difference between the two groups was statistically significant(P=0.015).Conclusion For the treatment of vertebral artery stenosis,domestic rapamycin-eluting stenting is safe and effective,it can reliably reduce the incidence of postoperative in-stent restenosis.

关 键 词：雷帕霉素 药物洗脱支架 椎动脉狭窄 支架内再狭窄 

分 类 号：R543.4[医药卫生—心血管疾病]