注射用丹参多酚酸盐治疗冠心病的临床疗效及其安全性  

Clinical efficacy and safety of salvianolate for injection in the treatment of coronary heart disease

作　　者：万婷 WAN Ting(Department of Pharmacy,Nancheng People's Hospital,Nancheng 344700,China)

机构地区：[1]江西省南城县人民医院药剂科,344700

出　　处：《临床合理用药杂志》2020年第30期12-14,17,共4页Chinese Journal of Clinical Rational Drug Use

摘　　要：目的探讨注射用丹参多酚酸盐治疗冠心病的临床疗效及其安全性。方法选取南城县人民医院2019年1月—2020年1月收治的冠心病患者70例,随机分为对照组和观察组,每组35例。对照组采取常规治疗,观察组在对照组基础上给予注射用丹参多酚酸盐。比较2组病情好转时间、心功能好转2级时间和住院时间,治疗前后左心室舒张末期内径、左心室收缩末期内径、左心室射血分数、心功能等级、血清脑钠肽水平、6 min步行距离,并比较2组临床疗效,治疗前后心脏疾病生活质量量表评分,并观察2组不良反应发生情况。结果观察组病情好转时间、心功能好转2级时间和住院时间短于对照组(P<0.05)。治疗前2组左心室舒张末期内径、左心室收缩末期内径、左心室射血分数、心功能等级、血清脑钠肽水平、6 min步行距离比较,差异无统计学意义(P>0.05);治疗后观察组左心室舒张末期内径、左心室收缩末期内径、左心室射血分数、心功能等级、血清脑钠肽水平低于对照组,6 min步行距离长于对照组(P<0.05)。观察组总有效率高于对照组(P<0.05)。治疗前2组心脏疾病生活质量量表评分比较,差异无统计学意义(P>0.05);治疗后观察组心脏疾病生活质量量表评分高于对照组(P<0.05)。2组治疗过程均未出现明显不良反应,仅各有1例出现轻微恶心。结论注射用丹参多酚酸盐治疗冠心病的临床疗效确切,可加速患者病情好转,促进患者心功能改善,并可有效改善患者血清学指标和提升其运动耐力,促进患者生活质量提高,且安全性较高。Objective To investigate the clinical efficacy and safety of salvianolate for injection in the treatment of coronary heart disease.Methods A total of 70 cases of patients with coronary heart were selected from January 2019 to January 2020 in Nancheng People’s Hospital,which were randomly divided into control group and observation group,35 cases in each group.The control group was given conventional treatment,and the observation group was given salvianolate for injection based on the control group.The improvement time,cardiac function improvement grade 2 time and hospitalization time,left ventricular end diastolic diameter,left ventricular end systolic diameter,left ventricular ejection fraction,cardiac function grade,serum brain natriuretic peptide level,6 min walking distance before and after treatment were compared between the two groups.The clinical efficacy,the score of heart disease quality of life scale before and after treatment were compared between the two groups.The incidence of adverse reactions was observed.Results The improvement time,heart function improvement time and hospitalization time of the observation group were shorter than the control group(P<0.05).Before treatment,there was no significant difference in left ventricular end diastolic diameter,left ventricular end systolic diameter,left ventricular ejection fraction,cardiac function grade,serum brain natriuretic peptide level and 6 minute walking distance between the two groups(P>0.05).After treatment,the left ventricular end diastolic diameter,left ventricular end systolic diameter,left ventricular ejection fraction,cardiac function grade,serum brain natriuretic peptide level in the observation group were lower than the control group,and the 6 minute walking distance was longer than the control group(P<0.05).The total effective rate of the observation group was higher than the control group(P<0.05).Before treatment,there was no significant difference in the scores of the two groups(P>0.05);after treatment,the score of the observation grou

关 键 词：冠心病 注射用丹参多酚酸盐 治疗结果 安全性 

分 类 号：R541.4[医药卫生—心血管疾病]