不同抗组胺药物联合布地奈德雾化吸入治疗小儿哮喘急性发作的临床疗效  

Analysis of Clinical Efficacy of Different Antihistamine Drugs Combined with Budesonide Inhalation Inhalation in the Treatment of Acute Asthma Attacks in Children

作　　者：刘月娇 徐浩[1] 闻德亮[2] LIU Yue-Jiao;XU Hao;WEN De-Liang(Department of Pediatrics,Central Hospital Affiliated to Shenyang Medical College,Shenyang 110024,China;China Medical University,Shenyang 110024)

机构地区：[1]沈阳医学院附属中心医院儿科,沈阳110024 [2]中国医科大学,沈阳110024

出　　处：《中国药物经济学》2020年第10期63-66,共4页China Journal of Pharmaceutical Economics

摘　　要：目的探讨不同抗组胺药物联合布地奈德雾化吸入治疗小儿哮喘急性发作的临床疗效。方法选取2018年3月至2019年10月沈阳医学院附属中心医院接收的93例哮喘急性发作患儿作为研究对象,根据用药不同分为两组,对照组(n=41)采用氯雷他定联合布地奈德吸入治疗,观察组(n=52)采用西替利嗪联合布地奈德吸入治疗。比较两组患者临床疗效、症状消失时间、免疫与炎症指标、肺功能指标及药物治疗后不良反应。结果观察组治疗有效率96.15%高于对照组90.24%,但差异无统计学意义(χ2=0.530,P>0.05);观察组哮鸣音、喘息、咳嗽消失时间显著短于对照组,差异有统计学意义(P<0.05);观察组治疗后外周血淋巴细胞计数(PBL计数)、CD4+/CD8+、白细胞介素-6(IL-6)、白细胞介素-10(IL-10)、C反应蛋白(CRP)改善程度优于对照组,差异有统计学意义(P<0.05);治疗后,观察组第一秒钟用力呼气容积(FEV1)、呼气峰流速(PEF)、用力肺活量(FVC)显著高于对照组,差异有统计学意义(P<0.05)。两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论西替利嗪联合布地奈德治疗小儿哮喘急性发作效果确切,能快速缓解症状、调节免疫炎症反应及改善肺功能。Objective To compare the therapeutic effect of different antihistamine drugs combined with budesonide inhalation in children with acute asthma attacks. Methods From March 2018 to October 2019, a total of ninety—three patients with acute asthma patients admitted to Central Hospital Affiliated to Shenyang Medical College were selected as the research objects and were divided into two groups according to different medications. The control group(n=41) was treated with loratadine combined with budesonide inhalation. The observation group(n=52) was treated with cetirizine combined with budesonide inhalation. The clinical efficacy, time of symptom disappearance, immune and inflammation index, lung function indexes and adverse reactions after drug treatment were compared between the two groups. Results The total effective rate of the observation group was 96.15% higher than that of the control group 90.24%, but the difference was not statistically significant(χ~2=0.530, P>0.05);the improvement time of wheezing, and cough disappearance time the observation group were significantly shorter than that of the control group, the difference was statistically significant(P<0.05);peripheral blood lymphocyte count(PBL count), CD4^+/CD8^+, IL-6, IL-10, CRP after treatment in the observation group was better than the control group, the difference was statistically significant(P<0.05);the forced expiratory volume in the first second(FEV1), peak expiratory flow rate(PEF), and forced vital capacity(FVC) in the observation group were significantly higher than those in the control group, the difference was statistically significant(P<0.05). There was no significant difference in adverse reactions between the two groups(P>0.05). Conclusion Cetirizine combined with budesonide is effective in the treatment of acute asthma in children. It can quickly relieve symptoms, regulate immune inflammation and improve lung function.

关 键 词：小儿 哮喘 抗组胺药 激素 布地奈德 西替利嗪 

分 类 号：R725.6[医药卫生—儿科] R985[医药卫生—临床医学]