雷公藤多苷片辅助缬沙坦治疗糖尿病肾病Ⅳ期患者的临床疗效及对肾功能的影响  

Clinical Efficacy and Influence on Renal Function of Tripterygium Wilfordii Tablets Assisting with Valsartan in the Treatment of Diabetic Nephropathy in Stage IV

作　　者：马秀宁[1] MA Xiu-Ning(Department of Nephrology,Second People's Hospital of Dalian,Dalian 110063,China)

机构地区：[1]大连市第二人民医院肾内科,辽宁大连110063

出　　处：《中国药物经济学》2020年第10期87-90,94,共5页China Journal of Pharmaceutical Economics

摘　　要：目的探讨雷公藤多苷片辅助缬沙坦治疗糖尿病肾病Ⅳ期患者的临床疗效及对肾功能的影响。方法选取2017年8月至2019年10月于大连市第二人民医院接受治疗的69例糖尿病肾病Ⅳ期患者作为研究对象,随机分为对照组(37例)和观察组(32例)。对照组在糖尿病基础治疗基础上加用缬沙坦,观察组在对照组基础上加用雷公藤多苷片,比较两组治疗效果、炎症介质、血脂代谢、肾功能指标及不良反应情况。结果观察组治疗有效率为93.8%,高于对照组的73.0%(P<0.05);与治疗前比较,治疗后两组低密度脂蛋白胆固醇(LDL-C)、三酰甘油(TG)、总胆固醇(TC)水平降低,且观察组低于对照组,差异有统计学意义(P<0.05);与治疗前比较,治疗后两组白细胞介素-6(IL-6)、C反应蛋白(CRP)和肿瘤坏死因子-α(TNF-α)水平降低,且观察组低于对照组,差异有统计学意义(P<0.05);与治疗前比较,治疗后两组血清肌酐(Scr)、24 h尿蛋白定量(24 hUTP)、血尿素氮(BUN)、尿肌酐(UCr)、尿酸(UA)水平降低,且观察组低于对照组,差异有统计学意义(P<0.05);两组患者未出现严重不良反应,观察组不良反应发生率稍高于对照组,但差异无统计学意义(P>0.05)。结论糖尿病肾病Ⅳ期患者应用雷公藤多苷片与缬沙坦联合治疗,可有效改善患者肾功能。Objective To study the effect of tripterygium wilfordii polyglycoside tablets combined with valsartan in the treatment of diabetic nephropathy in stage IV. Methods A total of sixty-nine patients with stage IV diabetic nephropathy who were admitted to Second People’s Hospital of Dalian from August 2017 to October 2019 were selected as the research objects and were divided into a control group(thirty-seven cases) and an observation group(thirty-two cases). The control group was treated with valsartan on the basis of basic treatment of diabetes, and the observation group was treated with tripterygium wilfordii tablets on the basis of the control group. The treatment effect, inflammatory factors, blood lipid metabolism, renal function indexes and adverse reactions of the two groups were compared. Results The total effective rate of treatment in the observation group was 93.8%, higher than that in the control group, 73.0%,(P<0.05);compared with those before treatment, the levels of low-density lipoprotein cholesterol(LDL-C), triacylglycerol(TG), total cholesterol(TC) levels in the two groups were lower after treatment, and the observation group was lower than the control group, the difference was statistically significant(P<0.05);compared with those before treatment, the levels of Interleukin-plasma 6(IL-6), C-reactive protein(CRP) and tumor necrosis factor-α(TNF-α) levels in the two groups decreased after treatment, and the observation group was lower than the control group(P<0.05);compared with those before treatment, after treatment, both the levels of serum creatinine(Scr), 24 h urine protein quantification(24 hUTP), blood urea nitrogen(BUN), urine creatinine(UCr), uric acid(UA) levels in the two group decreased, and the observation group was lower than the control group, the difference was statistically significant(P<0.05);there were no serious adverse reactions in the two groups, and the incidence of adverse reactions in the observation group was slightly higher than that in the control group, the difference

关 键 词：雷公藤多苷片 缬沙坦 糖尿病肾病 肾功能 不良反应 

分 类 号：R587.2[医药卫生—内分泌] R287[医药卫生—内科学]