鸢尾素通过整合素αV受体对衰竭心脏的保护作用  

Irisin mediates protective effects on failing heart via integrin alpha V receptors

作　　者：王静[1] 毋江波[1] Wang Jing;Wu Jiangbo(Tianjin University of Sport,Tianjin 301617,China)

机构地区：[1]天津体育学院,天津市301617

出　　处：《中国组织工程研究》2021年第20期3219-3225,共7页Chinese Journal of Tissue Engineering Research

基　　金：天津市自然科学基金青年项目(18JCQNJC12400),项目负责人:毋江波;天津市“131”创新型人才培养工程第三层次,项目负责人:毋江波。

摘　　要：背景:运动诱导骨骼肌、心肌和脂肪等组织分泌鸢尾素,它可通过自分泌、旁分泌和内分泌途径对肌肉和非肌肉组织发挥各种作用。临床上把血清鸢尾素水平作为诊断心力衰竭和评价其严重程度的重要指标及治疗心力衰竭的潜在靶点。目的:从鸢尾素受体角度探讨运动诱导的鸢尾素发挥心肌保护作用的机制。方法:检索sCI、Pubmed及CNKI等数据库1990至2020年相关文献,英文检索词为"Irisin;IntegrinαV;aerobic exercise;chronic heart failure;myocardial mitochondria";中文检索词为"鸢尾素;整合素αV;有氧运动;慢性心衰;心肌线粒体"。按纳入标准和排除标准筛选,选取权威性和有代表性的文献68篇进行综述。结果与结论:鸢尾素对维持正常的心功能有重要作用,鸢尾素诱导的心脏保护与线粒体功能改善有关。整合素αV是新发现的鸢尾素特异性受体,它可以通过外-内信号把细胞外信号传导到细胞内。研究发现了整合素αV介导了鸢尾素对心肌线粒体氧化应激、生物合成和自噬的作用,这为有氧运动/鸢尾素改善心衰提供了一种新疗法。BACKGROUND:Exercise stimulates skeletal muscle,myocardium and fat tissues to release irisin,and it exerts various effects on muscle and non-muscle tissues through autocrine,paracrine and endocrine pathways.Clinically,serum irisin level is used as an important indicator for diagnosing heart failure and evaluating its severity as well as a potential target for treating heart failure.OBJECTIVE:To explore the mechanism by which exercise-induced irisin exerts myocardial protection from the perspective of receptors.METHODS:SCI,PubMed,and CNKI were searched for relevant documents published from 1990 to 2020.The search terms included"irisin;integrinαV;aerobic exercise;chronic heart failure;myocardial mitochondria"in English and Chinese,respectively.According to the inclusion criteria and exclusion criteria,68 authoritative and representative literatures were selected for review.RESULTS AND CONCLUSION:Irisin plays an important role in maintaining normal cardiac function,and its cardioprotection is related to the improvement of mitochondrial function.IntegrinαV is a novel specific receptor of irisin,which can transmit extracellular signals into cells through outside-in signals.IntegrinαV mediates the effects of irisin on myocardial mitochondria,including oxidative stress,biosynthesis and mitophagy,which provides a new therapy for aerobic exercise or irisin to improve heart failure.

关 键 词：运动 鸢尾素 整合素 心肌保护 综述 

分 类 号：R446[医药卫生—诊断学] R496[医药卫生—临床医学]