Syntheses, Crystal Structures and Biological Activity of the Diorganotin 2-(2-(4-Methoxybenzoyl)hydrazono)-3-phenylpropanoic Carboxylate Complexes  

作　　者：WANG Man YU Fei JIANG Wu-Jiu TAN Yu-Xing ZHANG Fu-Xing KUANG Dai-Zhi 

机构地区：[1]Key Laboratory of Functional Metal-organic Compounds of Hunan Province,Key Laboratory of Functional Organometallic Materials,University of Hunan Province,College of Chemistry and Materials Science,Hengyang Normal University,Hengyang,Hunan 421008,China

出　　处：《Chinese Journal of Structural Chemistry》2020年第11期1965-1972,共8页结构化学（英文）

基　　金：Supported by Hengyang Normal University College Students Scientific and Technological Works Project (No. 167 and 168);Foundation of Key Laboratory of Functional Organometallic Materials,University of Hunan Province (No. GN19K07);Scientific Research Fund of Hunan Provincial Education Department of China (No. 19C0279);Hengyang Normal University Industrial Supported Project (Nos. HXKJ201908,HXKJ201911,HXKJ201946 and HXKJ201947)。

摘　　要：Diorganotin 2-(2-(4-methoxybenzoyl)hydrazono)-3-phenylpropanoic carboxylate complexes Ⅰ{[p-CH3 O-C6 H4 O(O)C=N-N=C(Ph CH2)COO](n-Bu)2 Sn(CH3 OH)}2 and Ⅱ {[p-CH3 O-C6 H4 O(O)C=NN=C(Ph CH2)COO](Ph CH2)2 Sn(CH3 OH)}2 have been synthesized. The complexes have been characterized by IR, 1 H, 13 C and 119 Sn NMR spectra, HRMS, elemental analysis, thermal stability analysis and the crystal structures have been determined by X-ray diffraction. The crystal of complex I belongs to triclinic system, space group P1 with a = 10.437(2), b = 11.576(3), c = 13.085(3) ?, α = 66.272(2)°, β = 86.920(3)°, γ = 73.367(3)°, Z = 2, V = 1383.3(5) ?3, Dc = 1.381 Mg·m-3, m(Mo Kα) = 0.959 mm-1, F(000) = 592, R = 0.0233 and w R = 0.0644. The crystal of complex Ⅱ is of triclinic system, space group P1 with a = 10.446(1), b = 11.720(1), c = 13.063(2) ?, α = 84.190(1)°, β = 71.610(1)°, γ = 72.624(1)°, Z = 1, V = 1448.3(3) ?3, Dc = 1.475 Mg·m-3, m(Mo Kα) = 0.925 mm-1, F(000) = 656, R = 0.0169 and w R = 0.0432. In vitro antitumor activities of both complexes were evaluated by MTT against three human cancer cell lines(NCI-H460, Hep G2 and MCF7), and two complexes exhibited good antitumor activity. The interaction between complex Ⅰ and calf thymus DNA were studied by UV-vis and fluorescence spectroscopy, the interaction of complex Ⅰ with calf thymus DNA were intercalation.

关 键 词：DIORGANOTIN CARBOXYLATE SYNTHESIS crystal structure biological activity 

分 类 号：TQ460.1[化学工程—制药化工]