大连地区居民非高密度脂蛋白胆固醇、低密度脂蛋白胆固醇与心血管危险因素聚集的相关性研究  

Association of non-high density lipoprotein cholesterol, low density lipoprotein cholesterin and cardiovascular risk factors in the residents of Dalian

作　　者：罗兰 董春江 李欣宇 高政南 Luo Lan;Dong Chunjiang;Li Xinyu;Gao Zhengnan(Department of Endocrinology and Metabolism,Dalian central Hospital affiliated to Dalian Medical University,Dalian 116033,China;Department of Neurology,967 Hospital of Chinese People′s Liberation Army,Dalian 116011,China)

机构地区：[1]大连医科大学附属大连市中心医院内分泌科,116033 [2]解放军第九六七医院神经内科,大连116011

出　　处：《中华糖尿病杂志》2020年第11期885-890,共6页CHINESE JOURNAL OF DIABETES MELLITUS

基　　金：国家科技支撑项目(2013BAI09B13)。

摘　　要：目的:研究大连地区居民非高密度脂蛋白胆固醇(non-HDL-C)、低密度脂蛋白胆固醇(LDL-C)与心血管危险因素聚集的相关性。方法:依托中华医学会发起的REACTION研究,选取2011年8至12月期间参加调查的大连地区随访的社区居民,共计10207人,在2014年7至12月期间进行随访。根据non-HDL-C、LDL-C值四分位将受试者分为Q1、Q2、Q3和Q4及q1、q2、q3和q4组,分析non-HDL-C、LDL-C与心血管危险因素聚集之间的相关性。组间均数比较采用单因素方差分析,相关分析采用Spearman相关分析、偏相关分析及二元logistic回归分析。结果:(1)Q1、Q2、Q3和Q4组心血管危险因素聚集的发生率为37.3%、42.1%、44.4%和51.6%,差异有统计学意义(χ2=35.361,P<0.001),q1、q2、q3和q4组心血管危险因素聚集的发生率为40.9%、42.6%、42.9%和49.2%,差异有统计学意义(χ2=19.888,P<0.001)。(2)Spearman相关分析显示在校正年龄、性别和吸烟情况进行的偏相关分析中,心血管危险因素聚集与non-HDL-C、LDL-C仍呈正相关(r=0.092、r=0.046,P<0.05)。(3)以2014年新发心血管危险因素聚集为终点事件,对随访数据行Cox回归分析,结果发现non-HDL-C和LDL-C分别与年龄、吸烟情况进入方程,差异均有统计学意义[non-HDL-C、年龄和吸烟情况的HR(95%CI)分别为:1.248(1.181~1.318)、0.988(0.980~0.996)、1.616(1.285~2.033);LDL-C、年龄和吸烟情况的HR(95%CI)分别为1.236(1.159~1.319)、0.990(0.982~0.997)、1.627(1.293~2.046),均P<0.05]。结论:(1)随着non-HDL-C和LDL-C的升高,大连地区居民心血管危险因素聚集的发生率呈逐渐增加趋势。(2)大连地区居民non-HDL-C和LDL-C均是心血管危险因素聚集的独立危险因素。Objective To investigate the relationship between non-high density lipoprotein cholesterol(non-HDL-C),low density lipoprotein cholesterin(LDL-C)and cardiovascular risk factors in the residents of Dalian.Methods Our sample was derived from the REACTION study.The data was collected from August 2011 to December 2011 in Dalian city,up to 10207 subjects.The follow-up data collected from July 2014 to December 2014.The subjects were divided into respective four groups according to the quartiles of non-HDL-C and LDL-C respectively,to compare the cardiovascular risk factors and other clinical parameters between the groups.Spearman correlation analysis,partial correlation analysis and binary Logistic regression model were used to analyze the relationship between non-HDL-C,LDL-C and cardiovascular risk factors,and the developments of cardiovascular risk factors clustering was compared in quartiles with Cox regression.Results(1)When comparing cardiovascular risk factors clustering with the non-HDL-C quartile level,there was statistically significant difference(χ²=35.361,P<0.001).When Comparing cardiovascular risk factors clustering with the LDL-C quartile level,there was statistically significant difference(χ²=19.888,P<0.001).(2)According to Spearman partial correlation analysis,adjusting for age,sex and smoking,analysis cardiovascular risk factors clustering was positively and significantly correlated with both non-HDL-C and LDL-C(r=0.092,0.046,P<0.05).(3)Define the development of cardiovascular risk factors clustering in 2014 as the endpoint with Cox regression analysis.It showed that both non-HDL-C and LDL-C,with age and smoking status into the equation,the differences were statistically significant[non-HDL-C,age and smoking status HR(95%CI):1.248(1.181-1.318),0.988(0.980-0.996),1.616(1.285-2.033);LDL-C,age and smoking status HR(95%CI):1.236(1.159-1.319),0.990(0.982-0.997),1.627(1.293-2.046),all P<0.05].Conclusion(1)With the increase of non-HDL-C or LDL-C levels,the prevalence rate of cardiovascular risk factors clust

关 键 词：非高密度脂蛋白胆固醇 低密度脂蛋白胆固醇 心血管危险因素聚集 大连地区 

分 类 号：R543.5[医药卫生—心血管疾病]