呼吸训练联合布地奈德福莫特罗治疗慢性阻塞性肺疾病稳定期的临床效果  

Clinical outcomes of respiratory training in combination with budesonide formoterol for stable chronic obstructive pulmonary disease

作　　者：李跃飞[1] 徐靖华[1] 杨永[1] 史晗冰[1] 李圣[1] Li Yuefei;Xu Jinghua;Yang Yong;Shi Hanbing;Li Sheng(Department of Emergency Medicine,Fourth Affiliated Hospital of Liaoning University of Traditional Chinese Medicine,Shenyang 110101,China)

机构地区：[1]辽宁中医药大学附属第四医院急诊科,沈阳110101

出　　处：《保健医学研究与实践》2020年第5期45-49,共5页Health Medicine Research and Practice

基　　金：辽宁省省直医院改革重点临床科室诊疗能力建设项目(辽财指社〔2015〕458号)

摘　　要：目的探讨呼吸训练联合布地奈德福莫特罗治疗慢性阻塞性肺疾病(COPD)稳定期的临床疗效。方法选取2017年1月-2019年12月辽宁省某医院收治的90例COPD稳定期患者为研究对象,采用随机数字表法分成对照组和实验组,每组45例。对照组患者给予布地奈德福莫特罗吸入剂治疗,实验组患者在对照组基础上配合呼吸训练进行治疗,均治疗16周。比较2组患者治疗前后肺功能指标[用力肺活量(FVC)、第1秒用力呼气容积(FEV1)、FEV1/FVC]、血清生化指标[白介素(IL)-17A、C反应蛋白(CRP)、IL-6]、血气分析指标[动脉血氧分压(PaO2)、动脉二氧化碳分压(PaCO2)]、生活质量[圣乔治呼吸问卷(SGRQ)评分]及临床疗效。结果实验组患者的治疗总有效率为95.56%,高于对照组的80.00%,差异有统计学意义(P<0.05)。治疗前,2组患者FVC、FEV1及FEV1/FVC水平比较,差异无统计学意义(P>0.05);治疗后,2组患者FVC、FEV1及FEV1/FVC水平均明显高于治疗前,且实验组患者高于对照组,差异均有统计学意义(P<0.05)。治疗前,2组患者PaCO2及PaO2水平比较,差异无统计学意义(P>0.05);治疗后,2组患者PaCO2水平均低于治疗前,PaO2水平均高于治疗前,且实验组患者PaCO2水平低于对照组,PaO2水平高于对照组,差异均有统计学意义(P<0.05)。治疗前,2组患者血清IL-17A、IL-6、CRP水平比较,差异无统计学意义(P>0.05);治疗后,2组患者IL-17A、IL-6、CRP水平均低于治疗前,且实验组患者低于对照组,差异均有统计学意义(P<0.05)。治疗前,2组患者SGRQ评分比较,差异无统计学意义(P>0.05);治疗后,2组患者SGRQ中肺部症状、活动能力、疾病影响维度评分均低于治疗前,且实验组患者低于对照组,差异均有统计学意义(P<0.05)。结论呼吸训练联合布地奈德福莫特罗有助于改善稳定期COPD患者炎症状态和肺功能,提高患者生活质量,临床疗效显著,值得推广。Objective To investigate the clinical efficacy of respiratory training combined with budesonide formoterol in the treatment of chronic obstructive pulmonary disease(COPD)in the stable stage.Methods Ninety patients with stable COPD admitted to a hospital in Liaoning Province from January 2017 to December 2019 were selected and divided into a control group and an experimental group with 45 patients in each group using a randomized numerical table.Patients in the control group were treated for 16 weeks with budesonide formoterol inhaler,and patients in the experimental group were treated for 16 weeks with respiratory training on the basis of the control group.Pulmonary functions Parameters[forced vital capacity(FVC),Forced expiratory volume in 1 second(FEV1),FEV1/FVC],serum biochemical parameters[interleukin(IL)-17A,C-reactive protein(CRP),IL-6],blood gas analysis parameters[arterial partial pressure of oxygen(PaO2),arterial partial pressure of carbon dioxide(PaCO2)],quality of life[St.George's Respiratory Questionnaire(SGRQ)score]and clinical efficacy were compared between the two groups before and after treatment.Results The total effective rate of treat-ment in the experimental group was 95.56%,which was higher than the 80.00%in the control group,and the difference was statistically significant(P<0.05).Before treatment,the levels of FVC,FEV1 and FEV1/FVC of the two groups were compared,and the difference was not statistically significant(P>0.05).After treatment,the levels of FVC,FEV1 and FEV1/FVC of both groups were significantly higher than before treatment,and those in the experimental group were higher than the control group;the differences were all statistically significant(P<0.05).Before the treatment,the PaCO2 and PaO2 levels of the 2 groups were compared,and the differences were not statistically significant(P>0.05).After the treatment,the PaCO2 level of both groups was lower than before the treatment,the PaO2 level was higher than before the treatment,the PaCO2 level of the experimental group was lower th

关 键 词：慢性阻塞性肺疾病 呼吸训练 布地奈德福莫特罗 肺功能 生活质量 炎症因子 

分 类 号：R563.9[医药卫生—呼吸系统]