特布他林雾化吸入治疗支气管哮喘急性发作患儿临床观察  

Clinical observation of nebulized inhalation of terbutaline in treating children with acute bronchial asthma

作　　者：李永安 陈巘 韩方方 LI Yong-an;CHEN Yan;HAN Fang-fang(Department of Pediatrics,Second Affiliated Hospital of Henan University of Science and Technology,Luoyang471003,P.R.China)

机构地区：[1]河南科技大学第二附属医院儿科,河南洛阳471003

出　　处：《社区医学杂志》2020年第20期1397-1399,共3页Journal Of Community Medicine

基　　金：河南省科技攻关(20150162)。

摘　　要：目的血清金属蛋白酶组织抑制因子-1(tissue inhibitor of metalloproteinase-1,TIMP1)和金属蛋白酶组织抑制因子-2(tissue inhibitor of metalloproteinase-2,TIMP2)参与支气管哮喘发病机制,而特布他林具有一定抗炎作用。本研究探讨特布他林雾化吸入治疗支气管哮喘急性发作患儿临床效果。方法选择2017-05-29-2019-05-29河南科技大学第二附属医院儿科收治的110例支气管哮喘急性发作期患儿作为研究对象,采用组间基本特征匹配的原则选择观察组和对照组,各55例。对照组接受常规治疗,观察组在对照组基础上接受特布他林雾化吸入治疗,比较两组患儿血清TIMP1、TIMP2、最大呼气流速峰值(peak expiratory flow,PEF)、第1秒最大呼气量(forced expiratory volume in one second,FEV1)及FEV1/用力肺活量(forced vital capacity,FEV1%)。结果治疗后,观察组TIMP1水平为(49.25±4.89)L,高于对照组的(42.36±6.02)L,t=6.588,P<0.001;TIMP2水平为(33.94±5.48)L,高于对照组的(30.24±3.32)L,t=4.282,P<0.001。治疗后,观察组PEF水平为(6.86±0.46)L/s,高于对照组的(5.76±0.36)L/s,t=13.966,P<0.001;观察组FEV1水平为(3.82±0.95)L,高于对照组的(3.18±0.81)L,t=3.802,P<0.001;观察组FEV1%水平为97.15±3.48,高于对照组的92.46±6.32,t=4.821,P<0.001。结论对于支气管哮喘急性发作患儿,应用特布他林雾化吸入可以有效调节TIMP1和TIMP2水平,改善患儿肺功能。OBJECTIVE Tissue inhibitor of metalloproteinase-1(TIMP1)and tissue inhibitor of metalloproteinase-2(TIMP2)are involved in the pathogenesis of bronchial asthma,while terbutaline has certain resistance inflammatory effect.This study explored the clinical effect of nebulized inhalation of terbutaline in the treatment of children with acute bronchial asthma.METHODS A total of 110children with acute bronchial asthma who were admitted to the Department of Pediatrics of the Second Affiliated Hospital of Henan University of Science and Technology from May 29,2017to May 29,2017were selected as the research object.55cases in each group.The control group received conventional treatment,and the observation group received terbutaline atomization inhalation treatment on the basis of the control group.The serum TIMP1,TIMP2,peak expiratory flow(PEF),forced expiratory volume in one second(FEV1)and FEV1/forced expiratory volume in one second predicted(FEV1%)were compared between the two groups.RESULTS After treatment,the TIMP1level of the observation group was(49.25±4.89)L,which was higher than that of the control group(42.36±6.02)L,t=6.588,P<0.001;The TIMP2level was(33.94±5.48),which was higher than that of the control group(30.24±3.32)L,t=4.282,P<0.001.After treatment,the PEF level of the observation group was(6.86±0.46)L/s,which was higher than that of the control group(5.76±0.36)L/s,t=13.966,P<0.001;The FEV1level of the observation group was(3.82±0.95)L,which was higher than that of the control group(3.18±0.81)L,t=3.802,P<0.001;The FEV1%level of the observation group was(97.15±3.48),which was higher than that of the control group(92.46±6.32),t=4.821,P<0.001.CONCLUSION For children with acute attacks of bronchial asthma,the application of terbutaline inhalation could effectively adjust the level of TIMP1and TIMP2and improve the lung function of the children.

关 键 词：特布他林雾化吸入 支气管哮喘 金属蛋白酶组织抑制因子-1 金属蛋白酶组织抑制因子-2 肺功能 

分 类 号：R725.6[医药卫生—儿科]