贝那普利结合曲美他嗪对冠心病合并心力衰竭的疗效及血浆脑钠钛的影响  

Effect of Benapril Combined with Trimetazidine on Coronary Heart Disease and Heart Failure and Plasma Naoh Titanium

作　　者：宋跃 吴立松[1] 刘冬[1] 曹剑[1] 宋邦荣 Song Yue;Wu Lisong;Liu Dong;Cao Jian;Song Bangrong(Cardiac Surgery,Beijing Anzhen Hospital,Capital Medical University,Beijing 100029,China)

机构地区：[1]首都医科大学附属安贞医院心外科,北京市100029

出　　处：《中国病案》2020年第10期103-106,共4页Chinese Medical Record

摘　　要：目的观察贝那普利结合曲美他嗪对冠心病合并心力衰竭的疗效及血浆脑钠钛的影响。方法选取2019年7月1日-2019年12月31日在某院接受治疗的66例冠心病合并心力衰竭的患者,随机将他们分成研究组和对照组。对照组采取强心利尿等常规药物加曲美他嗪的医治方法,研究组在对照组的基础上增加贝那普利展开医治。观察两组患者的临床疗效、治疗前后SBP和血浆BNP水平、心功能各指标以及治疗前后的各项功能指标的情况。结果研究组的临床疗效明显优于对照组的临床疗效(P<0.05);治疗前,研究组的SBP和血浆BNP水平较对照组的SBP和血浆BNP水平无明显的差异(P>0.05);研究组的心功能指标明显优于对照组的心功能指标(P<0.05);治疗前,研究组的各项功能指标较对照组无显著的差异(P>0.05);治疗后,研究组的各项功能指标明显优于对照组的各项功能指标(P<0.05)。结论在治疗冠心病合并心力衰竭的过程当中,使用贝那普利结合曲美他嗪的医治方法能够明显的减少患者的血浆脑钠肽的水平,从而进一步的改良患者的心功能,使用效果显著,临床上应当进一步推广使用。Objective To observe the effect of benapril combined with trimetazidine on coronary heart disease and heart failure and the effect of plasma naoh titanium.Methods 66 patients with coronary heart disease and heart failure who received treatment in our hospital from January 2016 to February 2018 were randomly divided into a study group and a control group.The control group was treated with a combination of trimetazidine and other conventional methods such as cardiac diuresis.The clinical efficacy,SBP and plasma BNP levels before and after treatment,cardiac function indicators and functional indicators before and after treatment were observed.Results The clinical efficacy of the study group was significantly better than that of the control group(P<0.05).Before treatment,the SBP and plasma BNP levels in the study group were not significantly different from those in the control group(P>0.05).The cardiac function index of the study group was significantly better than that of the control group(P<0.05).Before treatment,there was no significant difference between the functional indicators of the study group and the control group(P>0.05).After treatment,the functional indicators of the study group were significantly better than those of the control group(P<0.05).Conclusion In the treatment of coronary heart disease and heart failure in the process of using that captopril combined with trimetazidine treatment method can obviously reduce the level of plasma brain natriuretic peptide in patients with further improvement in patients with cardiac function,use the effect is remarkable,should further promote the use of clinical.

关 键 词：贝那普利 曲美他嗪 冠心病合并心力衰竭 疗效 脑肽钠 

分 类 号：R541.4[医药卫生—心血管疾病] R541.6[医药卫生—内科学]