癌症疼痛药物治疗理念的发展与变迁  

Development and Change of the Vision of Drug Treatment for Cancer Pain

作　　者：李文杰 刘金玉 司倩 陈元 张程亮 LI Wenjie;LIU Jinyu;SI Qian;CHEN Yuan;ZHANG Chengliang(Department of Pharmacy,People's Hospital of Zhengzhou,Zhengzhou 450003,China;Department of Pharmacy,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430030,China;Department of Oncology,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430030,China)

机构地区：[1]郑州人民医院药学部,郑州450003 [2]华中科技大学同济医学院附属同济医院药学部,武汉430030 [3]华中科技大学同济医学院附属同济医院肿瘤中心,武汉430030

出　　处：《医药导报》2021年第1期45-51,共7页Herald of Medicine

摘　　要：癌症疼痛(简称癌痛)是癌症患者的主要并发症之一,严重影响患者的生存质量。药物治疗是癌痛治疗的重要组成部分,合理利用现有药物和治疗知识,可以缓解大部分患者的癌痛。随着人们对于癌痛发病机制认识的深入以及药物临床研究的进步,癌痛药物治疗理念也在不断发展。该文简要介绍癌痛治疗的常用药物,基于WHO提出的三阶梯镇痛理念,围绕阶梯镇痛理念的发展、阿片滴定理念的变化、癌痛治疗目标的衍变等方面,阐述了近年来癌痛药物治疗相关领域的理念变化,以期为临床癌痛患者的药物治疗以及未来该领域的临床研究提供借鉴。Cancer-related pain(cancer pain)is the main complication of cancer patients,which seriously affects the patient’s survival quality.Drug treatment is an important part of cancer pain treatment.Reasonable use of existing drugs and treatment knowledge can relieve cancer pain in most patients.Nowadays,with the deepening understanding of the pathogenesis of cancer pain and the progress of clinical research on drugs,cancer pain drug treatment concept is constantly developing.In this review,the authors wrote a brief introduction of commonly used drugs for cancer pain.Then,based on the three-step analgesic concept proposed by the World Health Organization(WHO),we explained the concept changes in the fields of cancer pain related medicine,the development of the ladder analgesic concept,the change of opioid titration concept,the evolution of cancer pain treatment goals,etc.It is expected to provide references for the clinical treatment of patients with cancer pain and future clinical research in this field.

关 键 词：癌症疼痛 阿片类药物 阶梯镇痛 

分 类 号：R971.2[医药卫生—药品] R969.3[医药卫生—药学]