肾功能不全癌症疼痛患者阿片类药物的应用  

Use of Opioids for Cancer Pain in Patients with Renal Dysfunction

作　　者：吴菲[1] 沈爱宗 WU Fei;SHEN Aizong(Department of Pharmacy,the First Affiliated Hospital of USTC,Anhui Provincial Hospital,Hefei 230001,China)

机构地区：[1]中国科学技术大学附属第一医院(安徽省立医院)药剂科,合肥230001

出　　处：《医药导报》2021年第1期65-70,共6页Herald of Medicine

摘　　要：阿片类药物是控制癌症疼痛(简称癌痛)的重要药物,若品种及剂量使用不当,将会进一步造成肾脏损伤。癌症患者由于疾病本身或并发症的进展,可能会伴有肾功能不全。因此存在肾功能不全风险的癌痛患者,必须正确评估肾功能状态,结合疼痛程度和阿片类药物特性,正确选择药品品种和剂量。该文综述常用阿片类药物的药动学特征、肾功能不全患者和透析患者阿片类药物的选择等,以期为临床合理用药提供参考。Opioids are important drugs to control cancer pain.When the wrong kind of opioids or wrong dose are used,it will further cause kidney injury.Cancer patients may be associated with renal dysfunction due to the progression of the disease itself or complications.Therefore,cancer pain patients with the risk of renal dysfunction must correctly evaluate the state of renal function,and correctly select the variety and dose of drugs according to the degree of pain and the characteristics of opioids.This article reviews the pharmacokinetic characteristics of commonly used opioids and the selection of opioids in patients with renal dysfunction and dialysis patients,in order to provide clinical reference for rational use of opioids.

关 键 词：阿片类药物 肾功能不全 癌症疼痛 

分 类 号：R971.2[医药卫生—药品] R969.3[医药卫生—药学]