小儿盐酸普鲁卡因口服溶液治疗消化系统疾病等所致呕吐550例  

Effect of Children’s Procaine Hydrochloride Oral Liquid on Vomiting Caused by Digestive System Diseases in 550 Children

作　　者：徐菲飞 闫峻峰[1,2] 易小清 罗维楠 王尧[1] 串俊兰 XU Feifei;YAN Junfeng;YI Xiaoqing;LUO Weinan;WANG Yao;CHUAN Junlan(Sichuan Key Laboratory of Individualized Drug Therapy,Department of Pharmacy,Sichuan Provincial People's Hospital,Sichuan Academy of Medical Sciences,Chengdu 610072,China;School of Medicine,University of Electronic Science and Technology,Chengdu 610054,China)

机构地区：[1]四川省医学科学院·四川省人民医院药学部,个体化药物治疗四川省重点实验室,成都610072 [2]电子科技大学医学院,成都610054

出　　处：《医药导报》2021年第1期87-89,共3页Herald of Medicine

基　　金：四川省科技厅资助项目(2017YSZH0028)。

摘　　要：目的观察小儿盐酸普鲁卡因口服溶液对消化系统疾病等所致呕吐患儿的疗效,为该药的后续研究提供参考。方法收集2018年3月—2019年3月四川省人民医院儿科使用小儿盐酸普鲁卡因口服溶液患儿的临床资料,对其使用年龄、适应证、用法用量、不良反应、治疗效果等进行统计。结果共收集使用小儿盐酸普鲁卡因口服溶液患儿550例,年龄25 d~13岁;适应证以胃肠炎引起的呕吐为主,也适用于胃炎、扁桃体炎、肠系膜淋巴结炎、上呼吸道感染、胃肠功能紊乱等引起的呕吐;用法用量为新生儿及1岁以下儿童口服用量<1 mL,1岁儿童用量平均为1 mL,每增加1岁用量增加1 mL,临床最大使用剂量为10 mL;不良反应为变态反应、食欲下降;治疗效果为治愈467例,好转78例,无效5例。结论小儿盐酸普鲁卡因口服溶液对儿童消化系统疾病等引起的呕吐疗效好,不良反应少。Objective To observe the curative effect of children’s procaine hydrochloride oral liquid on children vomiting caused by digestive system diseases,and to provide clinical use data for its follow-up research.Methods From March2018 to March 2019,the clinical data of children’s procaine hydrochloride oral liquid used in pediatric department of Sichuan Provincial People’s Hospital were collected.The age,indications,usage,dosage,and the effect and adverse reactions of child patients were statistically analyzed.Results A total of 550 patients received procaine hydrochloride oral liquid,the range of their age from 25 days to 13 years.It was used for vomiting caused by gastroenteritis,also applicable to vomiting caused by gastritis,tonsillitis,mesenteric lymphadenitis,upper respiratory tract infection,gastrointestinal dysfunction.The dosage was less than 1 mL for newborns and children under 1 year old.The average dosage for children aged 1 year was 1 ml,the dosage for children aged over 1 year increased by 1 mL,and the maximum clinical dosage was 10 mL.Adverse reactions were allergic reactions and decreased appetite.The children got cured in 467 cases,improved in 78 cases,and ineffective in 5 cases.Conclusion Children’s procaine hydrochloride oral liquid is suitable for children,especially newborns.It has antiemetic or analgesic effect on vomiting and pain caused by digestive system diseases in children.

关 键 词：小儿盐酸普鲁卡因口服溶液 消化系统疾病 呕吐 儿童 

分 类 号：R985[医药卫生—药品] R975[医药卫生—药学]