逐层自组装技术在药物递送中的研究进展  

Research progress of layer-by-layer self-assembly technology in drug delivery

作　　者：邸金威 杜祎萌 高翔[1] 张慧 刘楠 郑爱萍 高静 DI Jin-wei;DU Yi-meng;GAO Xiang;ZHANG Hui;LIU Nan;ZHENG Ai-ping;GAO Jing(Institute of Pharmacology and Toxicology,Academy of Military Medical Sciences,Academy of Military Sciences,Beijing 100850,China)

机构地区：[1]军事科学院军事医学研究院毒物药物研究所,北京100850

出　　处：《药学学报》2020年第11期2595-2605,共11页Acta Pharmaceutica Sinica

基　　金：军事医学创新工程专项(16CXZ032);国家重大新药创制专项(2018ZX09J18107-003)。

摘　　要：近年来逐层自组装(layer-by-layer self-assembly,LbL)技术快速发展,因其制备简单、灵活和可控,已经在医药、冶金等各行业得到广泛应用。在药物递送系统研究中,采用LbL方法构建的中空微胶囊作为药物递送载体,在药物释放、体内循环及生物利用度方面具有很大的优势,为药物靶向释放提供了技术平台。本文总结了应用于LbL的成膜材料及自组装成膜的驱动力类型,简述了中空微囊的载药方式和载药种类,综述了自组装膜作为药物载体的释放机制、体内外评价和安全性评价,表明了LbL技术在药物递送方面的巨大应用前景。In recent years,layer-by-layer self-assembly(LbL)has developed rapidly.It has been widely used in various industries such as medicine and metallurgy because of its simplicity,flexibility and controllability.In the study of drug delivery system,hollow microcapsules constructed by LbL method as drug carrier have great advantages in drug release,circulation in vivo and bioavailability,providing a technical platform for targeted drug release.In this paper,we summarize the types of film-forming materials and the driving force used in LbL technology,the way of loading drug into hollow micro capsule,and the variety of loaded drugs.We focus on the release mechanism,its evaluation and safety evaluation of self-assembled film as drug carrier in vivo and in vitro.The review shows the great application prospect of LbL technology in the field of drug delivery.

关 键 词：逐层自组装 药物载体 刺激响应 生物材料 药物递送系统 

分 类 号：R943[医药卫生—药剂学]