褪黑素延缓哺乳动物衰老的作用及其机制的研究进展  

The Role of Melatonin in Delaying Aging and Related Mechanisms in Mammals

作　　者：高文婷 孙海基[1] 王德华[2,3] 张学英[2,3] GAO Wen-Ting;SUN Hai-Ji;WANG De-Hua;ZHANG Xue-Ying(College of Life Sciences,Shandong Normal University,Jinan 250014;State Key Laboratory of Integrated Management of Pest Insects and Rodents,Institute of Zoology,Chinese Academy of Sciences,Beijing 100101;CAS Center for Excellence in Biotic Interactions,University of Chinese Academy of Science,Beijing 100049,China)

机构地区：[1]山东师范大学生命科学学院,济南250014 [2]中国科学院动物研究所,农业虫害鼠害综合治理研究国家重点实验室,北京100101 [3]中国科学院生物互作卓越创新中心,中国科学院大学,北京100049

出　　处：《动物学杂志》2020年第6期797-805,共9页Chinese Journal of Zoology

基　　金：国家自然科学基金项目(No.31770440,31772461)。

摘　　要：褪黑素(melatonin)在哺乳动物中是主要由松果体分泌的一种多功能吲哚激素,具有抗氧化、调节睡眠、调节昼夜节律、增强免疫力、抑制肿瘤等作用,在哺乳动物的复杂衰老进程中发挥重要作用。本文从氧化应激和能量代谢两个方面综述了褪黑素在哺乳动物中延缓衰老的作用机制。褪黑素通过清除自由基、激发抗氧化作用以及保护线粒体功能从而减缓氧化应激;通过调节代谢感知、重建昼夜节律以及促进能量消耗调节能量代谢。最后对该领域今后可能的发展方向进行了展望。Melatonin is a multifunctional indole hormone mainly secreted by the pineal gland in mammals.It has been known that melatonin,as an antioxidant,regulates sleep and circadian rhythms,enhances immunity,suppresses tumors,and delays aging process of mammals.This review summarized the mechanisms by which melatonin plays its function in delaying aging in mammals from two aspects of oxidative stress and energy metabolism,including retarding oxidative stress by scavenging free radicals,stimulating antioxidation and protecting mitochondrial function,and regulating energy metabolism by modulating metabolic sensing,re-establishing circadian rhythm and promoting energy expenditure.Finally,the future development of this field is prospected.

关 键 词：褪黑素 线粒体 能量代谢 氧化应激 延缓衰老 

分 类 号：Q955[生物学—动物学]