宫腔灌注对反复种植失败患者妊娠结局的研究进展  

Research progress of intrauterine perfusion on pregnancy outcome in the patients with repeated implantation failure

作　　者：吕萌[1] 刘琳[1] Lyu Meng;Liu Lin(The First School of Clinical Medicine of Lanzhou University,the Reproductive Medicine Special Hospital of the First Hospital of Lanzhou University,Key Laboratory for Reproductive Medicine and Embryology of Gansu Province,Lanzhou 730000,China)

机构地区：[1]兰州大学第一临床医学院,兰州大学第一医院生殖医学专科医院,甘肃省生殖医学与胚胎重点实验室,730000

出　　处：《中华生殖与避孕杂志》2020年第10期798-804,共7页Chinese Journal of Reproduction and Contraception

基　　金：国家自然科学基金(81960279);国家青年基金(81401261);甘肃省自然科学基金青年科技项目(18JR3RA361);默克中国生殖医学研究基金(MerckSerono_CREATE-201615);兰大一院2018年度院内基金(ldyyyn2018-55)。

摘　　要：虽然辅助生殖技术(assisted reproductive technology,ART)的发展使不孕不育夫妇的临床妊娠率获得显著提升,但反复种植失败(repeated implantation failure,RIF)患者的妊娠成功率依然很低。RIF造成了胚胎资源的浪费、增加了患者的经济负担、加重患者的身心创伤,如何提高RIF患者的内膜容受性以期改善妊娠结局已成为目前辅助生殖领域亟待解决的临床难点和科研热点问题。宫腔灌注作为一种改善子宫内膜容受性的临床治疗方法在RIF患者中的使已较为普及,粒细胞集落刺激因子(granulocyte-colony stimulating factor,G-CSF)、人绒毛膜促性腺激素(human chorionic gonadotropin,hCG)、外周血单核细胞(peripheral blood mononuclear cells,PBMCs)是目前用于宫腔灌注的主要药物,宫腔灌注及这些药物对子宫内膜及子宫微环境发挥其特定的作用,改善RIF患者的妊娠结局。本文回顾了宫腔灌注G-CSF、hCG、PBMCs及其它药物对RIF患者妊娠结局及其相关机制的研究,旨在对宫腔灌注对RIF患者的影响作一综述。Although the development of assisted reproductive technology(ART)has significantly increased the clinical pregnancy rate of infertile couples,the success rate of pregnancy in patients with repeated implantation failure(RIF)is still very low.RIF causes the waste of embryonic resources,increases the financial burden of patients,and aggravates the physical and mental trauma of patients.How to improve the endometrial receptivity and pregnancy outcomes of the patients with RIF has become an urgent clinical and scientific research focus in the field of assisted reproduction.Intrauterine perfusion as a clinical treatment to improve endometrial receptivity has become more popular in the patients with RIF,granulocyte-colony stimulating factor(G-CSF),human chorionic gonadotropin(hCG),peripheral blood mononuclear cells(PBMCs)are the main drugs used for intrauterine perfusion at present.Intrauterine perfusion and these drugs play a specific role in endometrium and uterine micro-environment to improve pregnancy outcomes of the patients with RIF.In this paper,we retrospectively analyzed the effects of intrauterine infusion of G-CSF,hCG,PBMCs and other drugs on pregnancy outcomes and related mechanisms,and the effects of intrauterine infusion on patients with RIF.

关 键 词：宫腔灌注 反复种植失败 不孕症 生殖技术 辅助 

分 类 号：R714.8[医药卫生—妇产科学]