阴性症状评估量表4条目中文版在轻中度精神分裂症患者中的信效度研究  

Validation of the Chinese version of the 4-item Negative Symptom Assessment in schizophrenia patients with mild to moderate symptoms

作　　者：蒲城城[1] 黄冰洁 苗齐 马可 张丹 程章[1] 石川[1] 于欣[1] Pu Chengcheng;Huang Bingjie;Miao Qi;Ma Ke;Zhang Dan;Cheng Zhang;Shi Chuan;Yu Xin(Peking University Sixth Hospital,Peking University Institute of Mental Health,NHC Key Laboratory of Mental Health(Peking University),National Clinical Research Center for Mental Disorders(Peking University Sixth Hospital),Beijing 100191,China)

机构地区：[1]北京大学第六医院/北京大学精神卫生研究所/国家卫生健康委员会精神卫生学重点实验室(北京大学)/国家精神心理疾病临床医学研究中心(北京大学第六医院),100191

出　　处：《中华精神科杂志》2020年第6期508-511,共4页Chinese Journal of Psychiatry

基　　金：首都卫生发展科研专项(2018-4-4116);北京市科委重点项目(D171100007017002)。

摘　　要：目的:评估阴性症状评估量表4条目(4-item Negative Symptom Assessment,NSA-4)中文版在精神分裂症患者中的信效度。方法:纳入172例精神分裂症患者进行NSA-4中文版及阴性症状评定量表(Scale for Assessment of Negative Symptoms,SANS)、PANSS、卡尔加里精神分裂症抑郁量表(Calgary Depression Scale for Schizophrenia,CDSS)评估。采用Cronbachα系数评价NSA-4中文版的内部一致性,采用组内相关系数(intraclass correlation coefficients,ICC)评价评分者间一致性,以Spearman相关分析评价重测信度。采用Spearman相关分析,以NSA-4中文版与SANS的相关性评价其效标效度,与PANSS、CDSS的相关性评价其聚合效度和区分效度。结果:NSA-4中文版的Cronbachα系数为0.788,ICC为0.661~0.958,重测信度r=0.860。NSA-4中文版与SANS的相关系数为r=0.801,与PANSS总分、PANSS阴性症状分及总体阴性症状评定的相关系数为r=0.528~0.834,与PANSS阳性症状分、一般病理分、CDSS总分相关系数为r=0.069~0.358。结论:NSA-4中文版具有良好的信效度,适用于精神分裂症患者阴性症状的临床快速评定。Objectives This study aims to evaluate the reliability and validity of the Chinese version of the 4-item Negative Symptom Assessment(NSA-4)in patients with schizophrenia.Methods A total of 172 patients with schizophrenia were recruited and assessed with the Chinese version of NSA-4,the Scale for Assessment of Negative Symptoms(SANS),PANSS,and the Calgary Depression Scale for Schizophrenia(CDSS).Cronbach′sαwas computed to evaluate internal consistency.Intraclass correlation coefficients(ICCs)were computed to evaluate the inter-rater reliability and Spearman's correlation analysis was used to evaluate the test-retest reliability.Spearman′s correlation analyses were conducted between NSA-4 and SANS,PANSS,and CDSS to evaluate concurrent validity,convergent validity,and discriminant validity,respectively.Results Cronbach′sαfor the Chinese version of the NSA-4 was 0.788.ICCs were 0.661-0.958 and test-retest reliability was 0.860.The Chinese version of the NSA-4 showed satisfactory concurrent validity considering its high correlation with SANS(r=0.801),excellent convergent validity considering its high correlation with PANSS total score and negative symptom subscale score(r=0.528-0.834),and good discriminant validity considering its weak correlation with scores of the positive symptom subscale and general psychopathology subscale of PANSS and CDSS(r=0.069-0.358).Conclusion The Chinese version of the NSA-4 has good psychometric properties.It is useful for rapid assessment of negative symptoms in patients with schizophrenia.

关 键 词：精神分裂症 阴性症状 信度 效度 

分 类 号：R749.3[医药卫生—神经病学与精神病学]