环保型杀菌剂啶酰菌胺的合成  

Green Synthesis of A New Environmental Friendly Fungicide Boscalid

作　　者：尚宇 李飞 郭亚飞 SHANG Yu;LI Fei;GUO Ya-fei(Shaanxi Environmental Monitoring Center,Xi'an 710054,China)

机构地区：[1]陕西省环境监测中心站,陕西西安710054

出　　处：《精细化工中间体》2020年第5期12-15,共4页Fine Chemical Intermediates

摘　　要：研究了一种合成环保型杀菌剂啶酰菌胺的方法,并优化其合成工艺。以邻氯硝基苯和4-氯苯硼酸为原料,经过Suzuki偶联、还原、缩合3步反应合成啶酰菌胺。在优化的反应条件下,3步总收率≥43%(以邻氯硝基苯计),产物纯度98%;产物结构经IR、1H NMR、 MS确证。第1步Suzuki偶联反应中,优化的反应条件是无水碳酸钾作碱,催化剂四(三苯基膦)钯的用量为15%(以邻氯硝基苯计)。第2步还原反应温度为50℃。该工艺简单经济,条件温和,绿色环保。A method for the synthesis of fungicide boscalid, a new environmental friendly bactericide was studied and the synthetic process was further optimized. Boscalid was prepared using 1-chloro-2-nitrobenzene and 4-chlorophenylboronic acid as starting materials through a series of reactions including Suzuki coupling reaction,reduction and condensation. Under the optimal reaction conditions, the total yield of boscalid was over 43% based on1-chloro-2-nitrobenzene with a purity of 98%. The structure was confirmed by IR,1 H NMR, MS. In the first step,K2CO3 being used as alkali, 15% of catalyst Pd(PPh3)4 based on 1-chloro-2-nitrobenzen was used as the optimized condition. The optimal reaction temperature of the second reduction reaction is 50 ℃. This process is simple, mild,economical, and environmental friendly.

关 键 词：环保 杀菌剂 啶酰菌胺 合成 

分 类 号：S482.2[农业科学—农药学]