白芍总苷联合伐昔洛韦对生殖器疱疹病毒感染者 血清IL-2 IL-4 IL-17表达的影响  

Effects of total glucosides of paeony combined with valacyclovir on the expression of serum IL-2, IL-4 and IL-17 in genital herpesvirus infection

作　　者：廖卫东[1] 李静思[1] 郭艳梅[1] LIAO Weidong;LI Jingsi;GUO Yanmei(Ji’an Central People’s Hospital,Ji'an,Jiangxi 343000,China)

机构地区：[1]吉安市中心人民医院,江西吉安343000

出　　处：《中国艾滋病性病》2020年第11期1209-1212,1249,共5页Chinese Journal of Aids & STD

摘　　要：目的探讨白芍总苷联合伐昔洛韦对生殖器疱疹病毒感染者辅助治疗作用及对血清IL-2、IL-4、IL-17表达的影响。方法2017年2月至2019年2月确诊为生殖器疱疹的病人90例作为研究对象,并加入20例健康体检者(健康组)作为对照。90例病人根据是否服用白芍总苷胶囊分为实验组(n=45)和对照组(n=45)。对两组病人治疗前后IL-2、IL-4、IL-17水平进行检测,对临床数据如疾病评分、临床指标、免疫指标等进行统计记录。结果入选研究对象以感染时间<5年(52例,57.8%),HSV-2感染(43例,47.8%)、复发感染(62例,68.9%)为主;与健康组相比,发病后实验组、对照组IL-2水平降低,IL-4、IL-17水平升高,差异具有统计学意义(P<0.05),实验组治疗后IL-2水平高于对照组、IL-4、IL-17水平低于对照组,差异具有统计学意义(P<0.05);实验组患者IL-2浓度与疾病评分呈负相关关系,IL-4、IL-17与疾病评分呈正相关关系,相关系数分别为:r=-0.33,P=0.019、r=0.27,P=0.039、r=0.31,P=0.029;实验组在治疗后第1个月复发次数、复发总次数、总人数及平均复发次数均明显少于对照组(P<0.05),实验组病人临床指标(止疱时间、结痂时间、症状消失时间及皮损愈合时间)均明显短于对照组(P<0.05);实验组病人CD4+T淋巴细胞绝对计数及百分比明显高于对照组(P<0.05)。结论白芍总苷可能通过影响免疫因子IL-2、IL-4、IL-17的表达来增强伐昔洛韦的抗病毒治疗效果,对生殖器疱疹的治疗具有一定的辅助作用。Objective To investigate the effect of total glucosides of paeony combined with valacyclovir on the adjuvant treatment of genital herpesvirus infection and the expression of serum IL-2,IL-4 and IL-17.Methods 90 patients from February 2017 to February 2019 with genital herpes were enrolled as subjects,and 20 healthy subjects were included as controls.The experimental group(n=45)and the control group(n=45)were divided according to whether they took the total glucoside capsule.The levels of IL-2,IL-4 and IL-17 were measured before and after treatment in the two groups,and clinical data such as disease score,clinical index and immune index were recorded.Results The subjects were mainly infected for<5 years(52 cases,57.8%),HSV-2 infection(43 cases,47.8%)and recurrent infection(62 cases,68.9%).Compared with the healthy group,the levels of IL-2 in the experimental group and control group decreased after the onset,and the levels of IL-4 and IL-17 increased,with the difference statistically significant(P<0.05).After treatment,the level of IL-2 in the experimental group was higher than that in the control group,and the level of IL-4 and IL-17 was lower than that of the control group,with the difference statistically significant(P<0.05).Group IL-2 concentration was negatively correlated with disease score.IL-4,and IL-17 was positively correlated with disease score,the correlation coefficients were:r=-0.33,P=0.019,r=0.27,P=0.039,r=0.31,P=0.029,respectively.The number of relapses,the total number of relapses,the total number of people and the average number of relapses in the experimental group in the first month after treatment were significantly less than those in the control group(P<0.05).The clinical indicators(anti-blister time,crusting time,symptom disappearance time and skin lesion healing time)in the experimental group were significantly shorter than those in the control group(P<0.05).The absolute count and percentage of CD4+T cells in the experimental group were significantly higher than those in the control group(P<

关 键 词：白芍总苷 伐昔洛韦 生殖器疱疹 

分 类 号：R752.1[医药卫生—皮肤病学与性病学]