HIV/AIDS病人合并慢性肾脏病的研究进展  

Advances in the study of HIV/AIDS patients with chronic kidney disease

作　　者：杜丹丹 祖力米拉 舒占钧[2,3] DU Dandan;Zulimila;SHU Zhanjun(Xinjiang Medical University Fourth Hospital,Urumqi 830000,Xinjiang,China;Traditional Chinese Medicine Affiliated to Xinjiang Medical University,Urumqi 830000,Xinjiang;Sixth People’s Hospital of Xinjiang Uygur Autonomous Region,Urumqi 830000,Xinjiang)

机构地区：[1]新疆医科大学第四临床医学院,乌鲁木齐830000 [2]新疆医科大学附属中医医院,乌鲁木齐830000 [3]新疆维吾尔自治区第六人民医院,乌鲁木齐830000

出　　处：《中国艾滋病性病》2020年第11期1255-1257,1261,共4页Chinese Journal of Aids & STD

基　　金：新疆维吾尔自治区自然科学基金项目(2017D01C168)。

摘　　要：抗反转录病毒治疗(ART)延长了艾滋病病毒(HIV)感染者/艾滋病(AIDS)病人(简称HIV/AIDS病人)的预期寿命,提高了HIV/AIDS病人的生存率。随着HIV/AIDS病人的老龄化和长期服用ART药物的不良反应,HIV/AIDS病人罹患肾病的风险显著增加,为HIV/AIDS病人合并慢性肾脏病(CKD)创造了新的流行病学环境。HIV/AIDS病人合并CKD的肾脏病理类型也从经典型HIV相关肾病(HIVAN)转移到药物相关的肾损伤。ART药物替诺福韦的肾脏毒性一直是人们关注的一个领域。本文对HIV/AIDS病人中CKD的最新流行病学、病理分类、药物肾毒性和管理进行综述。Antiretroviral therapy(ART)significantly prolongs the life expectancy of patients with human immunodeficiency virus/acquired immune deficiency syndrome(HIV/AIDS)and improves their survival.With the aging of HIV/AIDS patients and the side effects of long-term use of ART drugs,the risk of kidney disease in HIV/AIDS patients has increased significantly,forming a new epidemiological surroundings for HIV/AIDS with chronic kidney disease(CKD).The incidence of renal pathological types in HIV/AIDS CKD patients has also shifted from typical HIV-associated nephropathy(HIVAN)to drug-related kidney injury.Renal toxicity of the ART drug tenofovir disoproxil fumarate(TDF)has attracted the concern.This article reviews the latest epidemiology,pathological classification,drug nephrotoxicity,and management of CKD in HIV/AIDS-infected population.

关 键 词：艾滋病 慢性肾脏病 流行病学 机制 病理 药物肾毒性 

分 类 号：R512.91[医药卫生—内科学] R373.9[医药卫生—临床医学]