白细胞介素-6/信号转导及转录活化因子3信号传导通路在心脏修复中的作用  

Effect of interleukin-6/signal transducer and activator of transcription 3 signaling pathway on heart repair

作　　者：聂抒[1] 张金鑫[1] 韩燕燕[1] Nie Shu;Zhang Jinxin;Han Yanyan(Department of Pediatric Cardiology,the First Hospital of Jilin University,Changchun 130021,China)

机构地区：[1]吉林大学第一医院小儿心血管科,长春130021

出　　处：《中华实用儿科临床杂志》2020年第23期1838-1840,共3页Chinese Journal of Applied Clinical Pediatrics

摘　　要：白细胞介素-6(IL-6)能修复多种组织损伤。IL-6信号通路中的关键转录因子——信号转导及转录活化因子3(STAT3)具有保护心脏的功能。研究发现,IL-6通过介导STAT3信号传导通路(IL-6/STAT3信号传导通路),在心脏创伤、心肌炎、心脏衰竭等多种心脏疾病造成的损伤中发挥促进心脏修复的作用。深入研究IL-6/STAT3信号传导通路对心脏疾病有积极的治疗意义,现就该通路在心脏修复中的作用进展进行综述。Interleukin-6(IL-6)is involved in the repair of various tissues.As a key transcription factor in IL-6 pathway,signal transducer and activator of transcription 3(STAT3)is required for heart protection.By inducing STAT3 activation,IL-6 signaling pathway could repair the cardiac damage in the healing process of many kinds of heart diseases,including cardiac injury,myocarditis and heart failure.Therefore,researches on the effect of IL-6/STAT3 pathway on heart repair has potential therapeutic implications for heart diseases.

关 键 词：白细胞介素-6 信号转导及转录活化因子3 信号传导 心脏修复 

分 类 号：R541[医药卫生—心血管疾病]