外泌体在血管疾病领域的研究进展及展望  

Research progress and prospects of exosomes in vascular diseases

作　　者：张昊 张雷 Zhang Hao;Zhang Lei(Department of Vascular Surgery,Changhai Hospital,Naval Military Medical University,Shanghai 200433,China)

机构地区：[1]上海海军军医大学附属长海医院血管外科,200433

出　　处：《中华实验外科杂志》2020年第12期2358-2361,共4页Chinese Journal of Experimental Surgery

基　　金：国家自然科学基金青年项目(81200225)。

摘　　要：外泌体是有多种细胞分泌的富含生物活性物质的纳米级囊泡,能够参与细胞间的信息传递,调节细胞的基因表达。在血管疾病领域,发挥着巨大的作用,能够参与血管再生与修复,与动脉粥样硬化、高血压、心肌梗死、主动脉夹层等疾病的发生和转归关系密切。外泌体具有相对固定的细胞靶向特性和更加明显的生物学活性,使其在疾病的诊断与治疗中具有巨大潜能。Exosomes are nano-scale vesicles rich in biologically active substances secreted by a variety of cells,which can participate in information transmission between cells and regulate cell gene expression.In the field of vascular diseases,it plays a huge role,participates in the regeneration and repair of vessels,and is closely related to the occurrence and outcome of diseases such as atherosclerosis,hypertension,myocardial infarction,and aortic dissection.Exosomes have relatively fixed cell targeting properties,which make them have great potential in the diagnosis and treatment of diseases.

关 键 词：外泌体 血管疾病 主动脉夹层 心肌梗死 动脉粥样硬化 

分 类 号：R54[医药卫生—心血管疾病]