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作 者:鲍瑶菲 薛茜茹 武海萍 邹秉杰 宋沁馨[1] 周国华 BAO Yaofei;XUE Qianru;WU Haiping;ZOU Bingjie;SONG Qinxin;ZHOU Guohua(Key Laboratory of Drug Quality Control and Pharmacovigilance of Ministry of Education,School of Pharmacy,China Pharmaceutical University,Nanjing 210009;Department of Clinical Pharmacy,Jinling Hospital,Medical School of Nanjing University,Nanjing 210002;School of Pharmaceutical Science,Southern Medical University,Guangzhou 510515,China)
机构地区:[1]中国药科大学药物质量与安全预警教育部重点实验室,南京210009 [2]东部战区总医院临床药学科,南京210002 [3]南方医科大学药学院,广州510515
出 处:《中国药科大学学报》2020年第6期635-645,共11页Journal of China Pharmaceutical University
基 金:国家自然科学基金资助项目(No.81673390);江苏省自然科学基金资助项目(No.BK20191322);江苏省杰出青年基金资助项目(No.BK20180005);大学生创新创业训练计划项目资助(No.202010316032S)。
摘 要:新型冠状病毒(SARS-CoV-2)引起的新型冠状病毒肺炎(corona virus disease 2019,COVID-19)在全世界范围内快速传播,截至2020年9月30日全球感染人数已达3300万人,造成100多万人死亡,给公众的生命健康造成严重威胁。基于实验室的标准化核酸检测方法周转时间长、成本高,因此急需开发便捷检测新冠病毒的方法,实现在资源有限的情况下快速测试以及时控制疫情。本文从提取、扩增、检测3个方面总结了针对新型冠状病毒所开发的核酸即时检测方法(point-ofcare testing,POCT),并对整合了这3个步骤的商业化即时检测装置进行简要介绍,以期为COVID-19及其他新兴传染病的紧急应对和快速部署提供参考。The corona virus disease 2019 (COVID-19) caused by the new coronavirus (SARS-CoV-2) has spreadrapidly around the world,posing a serious threat to the public's health. As of September 30,2020,the number ofinfected people in the world has reached 33 million,causing more than 1 million deaths. Normalized nucleic aciddetection methods based on lab have long turnaround time and high cost. Therefore,there is an urgent need todevelop a convenient method to detect SARS-CoV-2,so as to achieve rapid testing and timely control of theepidemic when resources are limited. This review summarizes the point-of-care testing (POCT) methodsdeveloped for SARS-CoV-2 in terms of extraction,amplification and detection,and briefly introduces commercialPOCT instruments that integrate these three steps,in order to provide references for emergency response andrapid deployment of COVID-19 and other emerging infectious diseases.
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