前列腺癌中热休克蛋白27作用的研究进展  

Research progress on the role of heat shock protein 27 in prostate cancer

作　　者：陈贤 郭文静 杨礼亮 周煜新 郭青龙[1] CHEN Xian;GUO Wenjing;YANG Liliang;ZHOU Yuxin;GUO Qinglong(Jiangsu Key Laboratory of Cancer Development and Intervention,Laboratory Research on Function of Natural Medicine Active Substance,China Pharmaceutical University,Nanjing 210009,China)

机构地区：[1]中国药科大学江苏省肿瘤发生与干预重点实验室,天然药物活性物质功能研究实验室,南京210009

出　　处：《中国药科大学学报》2020年第6期731-738,共8页Journal of China Pharmaceutical University

基　　金：国家自然科学基金资助项目(No.81703550);江苏省青年科学基金资助项目(No.BK20170749)。

摘　　要：前列腺癌是成年男性最常见的肿瘤之一,而热休克蛋白(HSPs)作为广泛参与多种肿瘤发病机制、诊断、治疗和预后的分子伴侣,在前列腺癌中发挥着重要的生物学功能,并且HSP27被认为是与前列腺特异性膜抗原类似的生物标志物。其中,热休克蛋白家族成员HSP27的表达增加与前列腺癌去势抵抗有关,并且能够促进肿瘤耐药、侵袭与骨转移,从而使前列腺癌更加难以治疗。因此,靶向前列腺癌中的HSP27可以作为一种有前景的肿瘤治疗策略。本文就HSP27的结构与功能、前列腺癌中HSP27介导的去势抵抗及以HSP27为靶点的抗肿瘤治疗研究进行综述,以期为临床中前列腺癌治疗方案提供新的理论依据。Prostate cancer is one of the most common cancers in adult men.Heat shock proteins(HSPs),as molecular chaperones widely involved in the pathogenesis,diagnosis,treatment and prognosis of various cancers,play crucial biological functions in prostate cancer and it can be considered as valuable biomarkers for cancer therapy,such as prostate-specific membrane antigen.As a member of the heat shock protein family,HSP27 is related to prostate cancer castration resistance,and its expression can promote tumor resistance,invasion and bone metastasis,making prostate cancer more invulnerable to treatments.Therefore,targeting HSP27 in prostate cancer can be perceived as one promising cancer treatment strategy.This article reviews the structure and function of HSP27,and its potential role on castration resistance and targeted therapy in order to provide a new theoretical basis for the clinical treatment of prostate cancer.

关 键 词：HSP27 前列腺癌 去势抵抗 肿瘤耐药 进展 

分 类 号：R965[医药卫生—药理学]