玉屏风颗粒对慢性阻塞性肺疾病急性发作期及后续稳定期患者肺功能、CAT评分、免疫功能的影响  

Effects of Yupingfeng granules on lung function,CAT score and immune function in patients with chronic obstructive pulmonary disease at acute stage and subsequent stable stage

作　　者：冯曙平 王戈菲[1] 陈翠 吴凡[1] 梁少红 周晓平[1] FENG Shuping;WANG Gefei;CHEN Cui;WU Fan;LIANG Shaohong;ZHOU Xiaoping(The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou 510150, Guangdong,China)

机构地区：[1]广州医科大学附属第三医院,广东广州510150

出　　处：《现代中西医结合杂志》2020年第36期4020-4023,4028,共5页Modern Journal of Integrated Traditional Chinese and Western Medicine

基　　金：广东省中医药局科研项目(20192051)。

摘　　要：目的探讨玉屏风颗粒对慢性阻塞性肺疾病(COPD)急性发作期及后续稳定期患者肺功能、CAT评分及免疫功能的影响。方法将2019年1月—2020年1月广州医科大学附属第三医院诊治的60例COPD急性发作期患者按照随机数字表法分为治疗组和对照组。对照组30例采用西医常规治疗,治疗组30例在对照组治疗基础上联合玉屏风颗粒治疗,2组疗程均为12周。比较2组临床疗效,观察2组治疗前及治疗4周、8周、12周慢性阻塞性肺疾病评估测试量表(CAT)评分,检测2组治疗前及治疗12周后CD4^+、CD8^+、CD4^+/CD8^+、IgG、IgM、IgA水平和肺功能,记录2组治疗12周内COPD急性发作频次。结果治疗组治疗12周后的总有效率为96.7%(29/30),对照组总有效率为80.0%(24/30),治疗组明显高于对照组(P<0.05)。治疗4周、8周、12周后,2组CAT评分均明显降低(P均<0.05),且治疗组明显低于同期对照组(P<0.05)。2组治疗12周后的CD4^+、CD4^+/CD8^+、IgA、IgG高于治疗前(P均<0.05),CD8^+、IgM水平均明显低于治疗前(P均<0.05),第一秒用力呼气容积(FEV1)、呼气峰流速(PEF)、FEV1/FVC均明显高于治疗前(P均<0.05),且治疗组各指标各指标改善情况均明显优于对照组(P均<0.05)。治疗组患者COPD急性发作频次明显少于对照组(P<0.05)。结论玉屏风颗粒可提高COPD急性发作后期的疗效,有利于控制病情,改善患者肺功能、免疫功能,减少急性发作频次。Objective It is to investigate the effects of Yupingfeng granules on lung function,CAT score,and immune function in patients with chronic obstructive pulmonary disease(COPD)during acute onset and subsequent stable periods.Methods Sixty patients with acute COPD diagnosed and treated in the Third Affiliated Hospital of Guangzhou Medical University from January 2019 to January 2020 were divided into treatment group and control group according to the random number table method.30 cases in the control group were treated with conventional western medicine,and 30 cases in the treatment group were treated with Yupingfeng granules on the basis of the treatment in the control group.The course of treatment in both groups was 12 weeks.The clinical efficacy of the two groups was compared,the CAT scores of the two groups before treatment and after 4 weeks,8 weeks,and 12 weeks of treatment were observed,the levels of CD4^+,CD8^+,CD4^+/CD8^+,IgE,IgM,IgA and lung function were detected before treatment and after 12 weeks of treatment,the frequency of acute COPD attacks in the two groups within 12 weeks of treatment was recorded.Results The total effective rate of the treatment group after 12 weeks of treatment was 96.7%(29/30),the total effective rate of the control group was 80.0%(24/30),and the treatment group was significantly higher than the control group(P<0.05).After 4 weeks,8 weeks,and 12 weeks of treatment,the CAT scores of the two groups were significantly reduced(P<0.05),and the treatment group was significantly lower than the control group in the same period(P<0.05).After 12 weeks of treatment,the levels of CD4^+,CD4^+/CD8^+,and IgA,IgG of the two groups were higher(all P<0.05),while the levels of CD8^+and IgM were significantly lower(all P<0.05),and the first second forced expiratory volume(FEV1),peak expiratory flow rate(PEF),FEV1/FVC were significantly higher than those before treatment(P<0.05),and the improvement of each index in the treatment group was significantly better than that in the control group(P both<0.0

关 键 词：玉屏风颗粒 慢性阻塞性肺疾病 急性发作期 稳定期 肺功能 CAT评分 免疫功能 

分 类 号：R563[医药卫生—呼吸系统]