肾康注射液对糖尿病肾病患者肾功能及血清TNF-α、MCP-1、IL-6的影响  

Effect of Shenkang injection on renal function and serum TNF-α,MCP-1,IL-6 in patients with diabetic nephropathy

作　　者：何立芳 李青科[1] 马玉霞[2] 任平香[2] 阎双缓[3] HE Li-fang;LI Qing-ke;MA Yu-xia;REN Ping-xiang;YAN Shuang-huan(Department of Nephrology, Tangshan People′s Hospital, Hebei Province, Tangshan 063001, China;Department of Nephrology, Tangshan FengRun People′s Hospital, Hebei Province,Tangshan 064000,China;Department of Infectious Disease, the Fifth Hospital of Shijiazhuang, Hebei Province, Shijiazhuang 050000, China)

机构地区：[1]河北省唐山市人民医院肾内科,河北唐山063001 [2]河北省唐山市丰润区人民医院肾内科,河北唐山064000 [3]河北省石家庄市第五医院感染科,河北石家庄050000

出　　处：《河北医科大学学报》2020年第12期1397-1400,共4页Journal of Hebei Medical University

基　　金：河北省医学科学研究重点课题(20181398)。

摘　　要：目的探讨肾康注射液对糖尿病肾病患者肾功能及血清肿瘤坏死因子α(tumor necrosis factor-α,TNF-α)、单核细胞趋化蛋白1(monocyte chemoattractant protein-1,MCP-1)、白细胞介素6(interleukin-6,IL-6)的影响。方法选取2型糖尿病合并肾病患者160例作为研究对象,采用随机数字表法分为对照组和观察组各80例,2组均接受常规治疗。对照组采用缬沙坦治疗,观察组在对照组基础上加用肾康注射液治疗,2组均治疗4周。比较2组治疗前后24 h尿蛋白定量(24-hour urinary protein quantification,UTP)、血肌酐(serum creatinine,SCr)、胱抑素C(Cystatin C)、血钾及血清TNF-α、MCP-1、IL-6水平。结果治疗后,2组患者UTP、SCr、Cystatin C及血清TNF-α、MCP-1、IL-6水平均明显低于治疗前,且观察组UTP、SCr、Cystatin C及血清TNF-α、MCP-1、IL-6水平均低于对照组,差异有统计学意义(P<0.05),治疗前后2组血钾水平差异无统计学意义(P>0.05)。结论肾康注射液可以有效降低糖尿病肾病患者UTP、SCr、Cystatin C水平,其机制可能是通过降低血清TNF-α、MCP-1、IL-6水平抑制炎症反应,发挥肾保护作用。Objective To investigate the effect of Shenkang injection on renal function and serum levels of Tumor necrosis factor-α(TNF-α),Monocyte chemoattractant protein-1(MCP-1),interleukin-6(IL-6)in patients with diabetic nephropathy.Methods A total of 160 patients with diabetic nephropathy were randomly divided into control group(n=80)and observation group(n=80).The control group was treated with valsartan 80 mg once a day,and the observation group was treated with Shenkang injection once a day on the basis of the control group,both groups were treated for 4 weeks.The 24-hour urinary protein quantification(UTP),serum creatinine(SCr),cystatin C(Cystatin C),plasma potassium,TNF-α,MCP-1 and IL-6 levels were compared between two groups before and after treatment.Results After treatment,the levels of UTP,SCr,Cystatin C and serum TNF-α,MCP-1 and IL-6 in two groups were significantly lower than those before treatment,and all indexes in the observation group were significantly lower than those in the control group(P<0.05).There was no significant difference in plasma potassium before and after treatment(P>0.05).Conclusion Shenkang injection can effectively reduce the levels of proteinuria,serum creatinine and cystatin C in patients with diabetic nephropathy,and its mechanism may be through reducing the levels of serum TNF-α,MCP-1 and IL-6,inhibiting inflammatory reaction and playing a protective role in kidney.

关 键 词：糖尿病肾病 肾康注射液 蛋白尿 血肌酐 

分 类 号：R587.24[医药卫生—内分泌]