磁共振3D-Tricks技术联合血清IL-6、anti-HSP60检测在输卵管性不孕临床诊断中的应用  

Application of magnetic resonance 3D-Tricks combined with serum IL-6 and anti-HSP60 detection in the diagnosis of tubal infertility

作　　者：李静[1] 文铁[2] 冯旭霞[1] LI Jing;WEN Tie;FENG Xu-xia(Department of CT, Affiliated Hospital of Yan'an University, Shaanxi Province, Yan′an 716000, China;Department of Radiology, Affiliated Hospital of Yan′an University, Shaanxi Province, Yan′an 716000, China)

机构地区：[1]延安大学附属医院CT诊断科,陕西延安716000 [2]延安大学附属医院放射科,陕西延安716000

出　　处：《河北医科大学学报》2020年第12期1439-1443,共5页Journal of Hebei Medical University

摘　　要：目的磁共振三维高时间分辨力动态增强成像(three-dimenstional time resolved imaging of contrast kinetics,3D-Tricks)技术联合血清白细胞介素6(interleukin-6,IL-6)、热休克蛋白60抗体(antibody to heat shock protein 60,anti-HSP60)检测在输卵管性不孕临床诊断中的应用价值。方法选取疑似输卵管性不孕症患者120例作为研究对象,并均行磁共振3D-Tricks技术和血清IL-6、anti-HSP60检测,分为三种检测方式:常规的血清IL-6+anti-HSP60、磁共振3D-Tricks技术、两种检测方式联合,以腹腔镜病理学结果为诊断金标准,分析比较IL-6、anti-HSP60阳性率,评估磁共振3D-Tricks技术联合血清IL-6、anti-HSP60检测在输卵管性不孕临床诊断中的检测诊断合格率、敏感度、特异度。结果120例患者中经腹腔镜病理学确诊有84例,其中联合组诊断符合率(96.43%)显著高于单独组(80.00%),且84例输卵管性不孕患者中血清anti-HSP60、IL-6阳性率均显著高于非输卵管性不孕患者,差异有统计学意义(P<0.05)。磁共振3D-Tricks技术以及血清IL-6、anti-HSP60平行联合检测诊断的敏感度显著高于磁共振3D-Tricks技术、血清IL-6、anti-HSP60单独检测(P<0.05),系列联合检测诊断的特异度显著高于两者的单独检测(P<0.05)。磁共振3D-Tricks技术以及血清IL-6、anti-HSP60联合检测的ROC曲线下面积显著高于单独检测(P<0.05)。结论磁共振3D-Tricks技术联合血清IL-6、anti-HSP60平行联合检测可提高输卵管性不孕临床诊断的敏感度,系列检测可提高输卵管性不孕临床诊断的特异度,对于输卵管性不孕的早期诊断具有重要价值。Objective To study clinical value of magnetic resonance three-dimenstional time resolved imaging of contrast kinetics(3D-Tricks)combined with serum interleukin-6(IL-6)and antibody to heat shock protein 60(anti-HSP60)detection in the diagnosis of tubal infertility.Methods A total of 120 patients with suspected tubal infertility were examined by magnetic resonance 3D-Tricks technique and serum IL-6 and anti-HSP60 detection.It was divided into three methods:routine serum IL-6 anti-HSP60,magnetic resonance 3D-Tricks technique and combination of two detection methods,and the results of laparoscopic pathology were taken as the diagnostic gold standard.The sensitivity and specificity of magnetic resonance 3D-Tricks combined with serum IL-6 and anti-HSP60 detection were evaluated and the positive rate of IL-6 and anti-HSP60 were investigated in the diagnosis of tubal infertility.Results Eighty-four cases were diagnosed by laparoscopy in 120 cases,among of which the diagnostic coincidence rate of combined group(96.43%)was significantly higher than that of single group(80.00%),and the positive rates of serum anti-HSP60 and IL-6 in 84 cases of tubal infertility were significantly higher than that of non-tubal infertility,with statistical significance(P<0.05).The sensitivity of parallel combined detection and diagnosis of magnetic resonance 3D-Tricks combined the detection of IL-6 anti-HSP60 was significantly higher than that of the single detection of 3D-Tricks and serum IL-6 and anti-HSP60(P<0.05),the specificity of series combined detection was significantly higher than that of both alone(P<0.05).The sensitivity of the series joint detection of magnetic resonance 3D-Tricks technique combined the detection of serum IL-6 and anti-HSP60 was significantly lower than that of parallel combined detection(P<0.05),and the specificity was significantly higher than that of parallel combined detection.The area under the ROC curve of magnetic resonance 3D-Tricks technique combined the detection of serum IL-6 and anti-HSP60 was signifi

关 键 词：不育 女(雌)性 白细胞介素6 热休克蛋白60抗体 

分 类 号：R711.6[医药卫生—妇产科学]