炎性因子与心房颤动患者射频消融术后早期复发的相关性  

Correlation Between Inflammatory Factors and Early Recurrence after Radiofrequency Ablation in Patients with Atrial Fibrillation

作　　者：孟庆红 杜雪莲[1] 宋坤青[1] 强媛媛 刘德敏 MENG Qing-hong;DU Xue-lian;SONG Kun-qing;QIANG Yuan-yuan;LIU De-min(Department of Cardiology,the Central Hospital of Cangzhou,Cangzhou,Hebei 061001,China;Department of Medical Examination Center,the Central Hospital of Cangzhou,Cangzhou,Hebei 061001,China)

机构地区：[1]沧州市中心医院心内科,河北沧州061001 [2]沧州市中心医院体检中心,河北沧州061001

出　　处：《解放军医药杂志》2020年第12期46-49,共4页Medical & Pharmaceutical Journal of Chinese People’s Liberation Army

基　　金：沧州市重点研发计划指导项目(183302012)。

摘　　要：目的观察炎性因子在心房颤动行射频消融术后早期复发患者中的表达情况,并探析炎症指标与心房颤动术后早期复发的相关性。方法回顾性分析2018年1月—2019年8月行射频消融术治疗的120例心房颤动患者的临床资料,按照射频消融术后3个月内是否出现复发进行分组,将其中早期出现复发的20例患者纳入早期复发组,其余未复发的100例患者纳入未复发组。比较2组超敏C反应蛋白(hs-CRP)、白介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)水平,绘制受试者工作特征(ROC)曲线,观察上述炎性因子水平预测心房颤动患者射频消融术后早期复发的价值。结果早期复发组的hs-CRP、IL-6、TNF-α水平均较未复发组明显升高(P<0.01);hs-CRP、IL-6和TNF-α预测心房颤动患者射频消融术后早期复发情况的界值分别为7.15 mg/L、9.48 pg/ml和18.05 pg/ml,曲线下面积分别为0.820(95%CI:0.702,0.938)、0.899(95%CI:0.802,0.996)和0.848(95%CI:0.750,0.946)。结论hs-CRP、IL-6、TNF-α水平对预测心房颤动患者行射频消融术后早期复发具有一定的价值。Objective To observe the expression of inflammatory factors in patients with early recurrence after atrial fibrillation undergoing radiofrequency ablation,and to explore the correlation between inflammatory indicators and early recurrence after atrial fibrillation.Methods A retrospective analysis of the clinical data of 120 patients with atrial fibrillation who underwent radiofrequency ablation from January 2018 to August 2019 was performed,and they were divided into groups according to presence or absence of recurrence within 3 months after radiofrequency ablation.Of them,20 patients with early recurrence were included in the early recurrence group,and the remaining 100 patients without recurrence were included in the non-recurrence group.The levels of high-sensitivity C-reactive protein(hs-CRP),interleukin-6(IL-6)and tumor necrosis factor-α(TNF-α)in the two groups were compared,receiver operating characteristic(ROC)curves were delineated,and the value of above-mentioned inflammation factor to predict the early recurrence of patients with atrial fibrillation after radiofrequency ablation was observed.Results The levels of hs-CRP,IL-6 and TNF-αin early recurrence group were significantly higher than those in non-recurrence group(P<0.01).The thresholds for hs-CRP,IL-6 and TNF-αto predict early recurrence after radiofrequency ablation in patients with atrial fibrillation were 7.15 mg/L,9.48 pg/ml and 18.05 pg/ml,respectively,and the areas under the curve were 0.820(95%CI:0.702,0.938),0.899(95%CI:0.802,0.996)and 0.848(95%CI:0.750,0.946),respectively.Conclusion The levels of hs-CRP,IL-6 and TNF-αhave certain values in predicting the early recurrence of patients with atrial fibrillation after radiofrequency ablation.

关 键 词：心房颤动 导管消融术 射频 超敏C反应蛋白 白介素-6 肿瘤坏死因子-α 复发 

分 类 号：R541.75[医药卫生—心血管疾病]