燃料丁醇研究进展及市场前景分析  

Research progress and commercialization prospect of fuel butanol

作　　者：张全 查孝胜 高慧鹏 李澜鹏 关浩[1] 刘自勇[2] 乔凯[1] 李福利[2] ZHANG Quan;ZHA Xiaosheng;GAO Huipeng;LI Lanpeng;GUAN Hao;LIU Ziyong;QIAO Kai;LI Fuli(Sinopec Dalian Petrochemical Research Institute,Dalian 116023,China;Qingdao Institute of Bioenergy and Bioprocess Technology,Chinese Academy of Sciences,Qingdao 266101,China;University of Chinese Academy of Sciences,Beijing 100049,China)

机构地区：[1]中国石化大连石油化工研究院,辽宁大连116023 [2]中国科学院青岛生物能源与过程研究所,山东青岛266101 [3]中国科学院大学,北京100049

出　　处：《生物加工过程》2020年第6期741-748,共8页Chinese Journal of Bioprocess Engineering

基　　金：中国石油化工股份有限公司自主课题(218018-3);国家自然科学基金(31800026)。

摘　　要：丁醇是一类重要的化工原料,可以作为车用液体燃料。本文中,笔者介绍了丁醇的生产方法(包括化学方法和生物发酵法)以及丁醇作为液体燃料在全球范围内的研究和应用进展;针对发酵法生产丁醇存在的问题,如原料成本高、溶剂毒性造成产物浓度低、丁醇产量及选择性低和生产过程成本高等,分析了近年来国内外主要研究进展,包括通过代谢工程和合成生物学手段提升丁醇的发酵产量,改善发酵产物选择性方面的工作以及通过混菌培养模式降低酶解生物质的成本等方面,由此可见相关研究有望改善微生物发酵法生产丁醇的经济性,推动可再生生物质能源的商业化进程。最后对丁醇国内外市场需求和生物丁醇的经济性进行分析,同时对生物丁醇的产业化前景进行预测。Butanol is an important chemical material that used as a liquid fuel for vehicles.This review introduces the production route of butanol,including chemical sources and biological fermentation,and summarizes the research and application progress of butanol as a liquid fuel on a global scale.We also address problems in the production of butanol by fermentation,such as high raw material cost,low product concentration caused by solvent toxicity,low butanol yield and selectivity,and high production process cost.We summarize and analyze the results of major research groups in recent years,especially the work in improving fermentation yield and product selectivity through metabolic engineering and synthetic biology methods,and reducing the cost of enzymatically hydrolyzed biomass through mixed bacteria culture mode.These latest developments are expected to improve the economics of fermentation production of butanol.Finally,the domestic and foreign markets of butanol and the economics of biobutanol are analyzed.

关 键 词：梭菌 丁醇 市场前景 生物燃料 液体燃料 合成生物学 代谢工程 可再生能源 

分 类 号：Q81[生物学—生物工程]