血清和肽素与多囊卵巢综合征患者胰岛素抵抗及动脉血管硬化的相关性研究  

Correlation of serum copeptin and insulin resistance and atherosclerosis of polycystic ovary syndrome patients

作　　者：刘贝贝[1] LIU Beibei(Department of Obstetrics,People's Hospital of Zhengzhou,Zhengzhou,Henan 450000,China)

机构地区：[1]郑州人民医院产科,河南郑州450000

出　　处：《中国医学工程》2020年第12期13-17,共5页China Medical Engineering

摘　　要：目的探讨多囊卵巢综合征(PCOS)患者血清和肽素水平与其并发症胰岛素抵抗(IR)及血管硬化的相关性。方法选取2018年1月至2019年10月在郑州人民医院就诊的100例PCOS患者作为PCOS组。择取同期该院体检的30~35岁健康育龄女性60例作为对照组。收集两组一般资料及常规体格资料,检测空腹血糖、空腹胰岛素、甘油三酯(TG)、总胆固醇(TC)、低密度脂蛋白(LDL)及高密度脂蛋白(HDL),以及和肽素水平,并计算胰岛素抵抗指数(HOMA-IR)。检测右侧肱踝脉搏波传导速度(ba-PWV)、颈动脉内膜厚度(IMT)等血管硬化指标。结果PCOS组体重指数(BMI)、TC、TG、HOMA-IR、ba-PWV、IMT及和肽素水平高于对照组(P<0.05)。Pearson相关性分析显示,和肽素与HOMAIR、ba-PWV及IMT呈正相关性(P<0.05)。多因素Logistic回归分析显示,高和肽素水平、肥胖是PCOS患者出现IR的独立危险因素(P<0.05);而高和肽素水平、高TC及高TG是PCOS患者出现AS的独立危险因素(P<0.05)。结论和肽素是PCOS患者出现IR和动脉血管硬化疾病的独立危险因素,检测PCOS患血清和肽素水平对其并发症IR和动脉血管硬化有预测价值。【Objective】To explore the correlation of serum copeptin of polycystic ovary syndrome(PCOS)patients and their insulin resistance(IR)and atherosclerosis.【Methods】One hundred PCOS patients were collected as PCOS group and 60 healthy women with childbearing age were collected as control group.The general data of the two groups were collected and the fasting glucose,fasting insulin,triglyceride(TG),total cholesterol(TC),low density lipoprotein(LDL)and high density lipoprotein(HDL)and serum copeptin were detected and the HOMA-IR were computed.The indices of atherosclerosis brachial and ankle pulse wave conduction velocity(ba-PWV),intima media thickness(IMT)of the artery were detected as well.【Results】The BMI,TC,TG,HOMA-IR,ba-PWV,IMT and serum copeptin in PCOS group were higher than those in control group(P<0.05).The results of Pearson correlation analysis showed that there were positive relationship of copeptin and HOMA-IR,ba-PWV,IMT.The results of Logistic regression analysis showed that high copeptin,obesity were the independent risk factors of IR,and high copeptin,high TC and high TG were the independent risk factors of AS for PCOS patients.【Conclusion】High copeptin is the independent risk factor of IR and AS of PCOS patients,and the detection of copeptin has the value for predicting complications of PCOS.

关 键 词：多囊卵巢综合征 动脉粥样硬化 危险因素 

分 类 号：R543.5[医药卫生—心血管疾病]